P. Gupta

RNA-binding protein FXR1 drives cMYC translation by mRNA circularization through eIF4F recruitment in ovarian cancer

This study identifies FXR1 as a driver of cMYC translation through mRNA circularization and eIF4F recruitment in ovarian cancer, linking FXR1 amplification to poor prognosis.

Repurposing the antidepressant sertraline as SHMT inhibitor to suppress serine/glycine synthesis addicted breast tumor growth.

This study repurposes sertraline as an inhibitor of serine hydroxymethyltransferase to target serine/glycine synthesis in breast cancer, showing synergistic antitumor effects with mitochondrial inhibitors.

Explosive sensing with insect-based biorobots

This study demonstrates a biorobotic chemical sensing system using locust brain signals to detect and distinguish explosive vapors rapidly.

Uncanny similarity of unique inserts in the 2019-nCoV spike protein to HIV-1 gp120 and Gag

The paper identifies four unique inserts in the 2019-nCoV spike protein that show similarity to HIV-1 gp120 and Gag, suggesting potential evolutionary links and implications for viral function and diagnosis.

Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification

This study identifies new TrmD inhibitors for mycobacterial infections using fragment-based drug discovery, showing activity against multiple mycobacterial species in vitro and in macrophage models.

Mito-SinCe2 Approach to Quantify Relationships between Mitochondrial Dynamics and Energetics status

The paper develops and validates mito-SinCe2, an approach to quantify the relationship between mitochondrial dynamics and energetics, revealing distinct states and linear relationships in ovarian tumor initiating cells.