Q. Liu

This study identifies differentially expressed proteins and phosphosites in porcine granulosa cells during follicular atresia, revealing potential biomarkers and pathways involved in the process.

This study investigates how gut microbiome-derived short-chain fatty acids (SCFAs) and their receptors FFAR2/FFAR3 regulate lung immune tone through IL-1β expression in mouse and human lung tissues.

This study conducts a meta-analysis of 12 articles to evaluate the protective effect of FMDV VP1 protein on animals, finding a significant protective effect with a combined effect value of -0.66.

This study identifies DNA polymerases alpha and delta as key mediators of geminivirus replication in plants, with C3 protein selectively recruiting polymerase delta for efficient viral genome synthesis.

This paper develops a nanoparticle-mediated method to enable in vivo analysis of RAS protein activity by delivering a fluorescent GTP analog into cells.

This study captures novel genomes from Saccharibacteria groups in humans and mammals, revealing convergent evolution and independent adaptation to human hosts.

This study identifies HCF-1 as a critical co-factor for MYC in driving mitochondrial and ribosome biogenesis gene expression, and shows its impact on cell growth and tumor progression.

This study shows that combining controlled-release urea with 300 kg ha-1 potassium chloride improves soil fertility, plant growth, and yield of Italian ryegrass.

This study reports the largest sequenced plant genome, Paris polyphylla var. yunnanensis, and identifies genes involved in polyphyllin biosynthesis.

This study investigates the interaction between honey bees, the mite T. mercedesae, and DWV, showing that honey bee antimicrobial peptides suppress mite reproduction.

This paper develops an in vivo protein kinase analysis method using chemical genetics and nanoparticle-mediated ATP analog delivery, demonstrating its applicability to AKT1.

This study shows that Bcl6 deletion in Treg cells reduces tumor growth by impairing their suppressive function, and increased Bcl6 expression is linked to poor cancer outcomes.

This study shows that blocking CTLA-4 reverses Treg cell suppression of anti-TB T-cell responses in tuberculosis patients.

This study identifies METTL5 as an 18S rRNA-specific m6A methyltransferase that modulates stress response gene expression by affecting translation.

This study evaluates the cytotoxicity of chloroquine and hydroxychloroquine in multiple cell lines and tissues using a dynamic imaging system and PBPK model, finding HCQ less toxic than CQ in most cases.

This study shows that ERAD deficiency causes mitochondrial dysfunction and transcriptional changes in human hepatic cells, linking ERAD to mitochondrial health.

This study compares non-Cochrane nursing systematic reviews with their PROSPERO-registered protocols, finding widespread discrepancies with few explanations.

The paper shows that KIF5B and KIF13B work together to transport secretory vesicles to microtubule plus ends, with KIF5B playing a dominant role and KIF13B assisting in reaching newly polymerized ends.

The paper identifies DHODH as a target of GSK983 and shows that combining it with pyrimidine salvage inhibitors like CPU enhances antiviral efficacy against dengue virus.

This study shows APOBEC3A promotes M1 macrophage polarization through RNA editing, affecting gene expression and cytokine secretion.

This study investigates the effects of human umbilical cord mesenchymal stem cell transplantation on preserving and restoring fertility in aging and chemotherapy-damaged female mice.

This study evaluates the in vivo efficacy and PK/PD of KBP-7072, an aminomethylcycline antibiotic, in pneumonia and thigh infection models, showing significant dose-dependent reductions in CFUs and improved survival.

This paper introduces a self-supervised workflow for automated particle picking in cryo-EM, achieving high-resolution reconstructions with minimal user input.

This study determines the crystal structure of AtMC4, revealing how Ca2+ activates plant metacaspase through linker domain cleavage and substrate access.

This study shows that the p53 variant Pro47Ser increases mTOR activity and metabolic efficiency in mouse and human cells through altered redox regulation of Rheb.

This paper introduces A-Star, a method for detecting rare mutations with high sensitivity and multiplexing capability, achieving detection as low as 0.01% allele frequency.

This study shows that osteopontin (OPN) is more abundant in symptomatic benign prostatic hyperplasia (S-BPH) compared to incidental BPH, and OPN secretion is stimulated by pro-inflammatory cytokines, driving pro-inflammatory gene expression in stromal cells.

The paper introduces a genetically encoded 1D 1H-NMR probe for studying conformational changes in large membrane protein complexes, demonstrating its effectiveness with minimal protein and time.