Q. Zhang

This study demonstrates sub-second, multichannel neural stimulation in flies using magnetic nanoparticles and temperature-sensitive ion channels, improving the temporal resolution of magnetogenetics.

The paper examines IFN-I autoantibodies in critical COVID-19 patients through longitudinal single-cell analysis, revealing suppressed ISG-I responses in myeloid cells.

This study evaluates antibody resistance and ACE2 usage in SARS-CoV-2 variants, finding SA501Y.V2 shows the highest resistance and expanded host range.

This study identifies recurrent chromosome fusions and gene losses in parrots, revealing the role of transposable elements and genetic drift in neo-sex chromosome evolution.

This study identifies BIRG1 as a chloride efflux transporter in rice that regulates grain size and salt tolerance by controlling chloride homeostasis.

This study examines how Brucella outer membrane proteins and mutants affect dendritic cell maturation and antigen presentation in mice, revealing their roles in immune evasion and pathogenesis.

The paper shows that the 501Y.V2 and 501Y.V3 SARS-CoV-2 variants have mutations that reduce binding to the antibody Bamlanivimab.

The paper introduces thiophosphopeptides that target the Golgi apparatus and selectively kill cancer cells through enzymatic self-assembly.

This study identifies ESR1 mutations as drivers of breast cancer metastasis by altering cell adhesion and migration through genomic and transcriptomic reprogramming.

The paper shows elevated Activin A and FLRG levels in COVID-19 patients predict severe outcomes like mechanical ventilation and mortality.

This paper investigates the increased transmissibility of the SARS-CoV-2 501Y.V1 variant due to the N501Y mutation in the Spike protein's RBD and its impact on ACE2 binding and vaccine efficacy.

This study shows pepper activates two different immune systems against Ralstonia solanacearum under high temperature and humidity, regulated by CaWRKY40 and cytokinins.

This study uses neutron crystallography to show that inhibitor binding changes protonation states of three histidine residues in SARS-CoV-2 Mpro, providing insights for drug design.

This study shows that disrupting FGF2 enhances thermogenesis in brown and beige fat, reducing obesity and hepatic steatosis in mice.

This paper develops a kinetic model of DnaA regulation in E. coli to explain how cell size and cell cycle are coordinated, reproducing experimental results and predicting responses to perturbations.

This paper develops statistical tools for analyzing spatial rotations in 3D cryoEM using unit quaternions to enable comparisons, interpolations, and inference of rotations.

The paper maps root-microbe interactions in Arabidopsis thaliana by identifying host genetic variants and microbial hubs that influence microbial network structures and functions.

This study shows E-cadherin interacts with EGFR to hyper-activate ERK, promoting proliferation in breast cancer models and identifying a potential therapeutic target.

This study reports cryo-EM structures of potent SARS-CoV-2 neutralizing antibodies, revealing bivalent binding mechanisms and their correlation with enhanced neutralization and S1 subunit shedding.

This study shows EsxA is internalized into host cells and inserts into host membranes, and surface-associated EsxAB enhances mycobacterial adherence and invasion.

This paper shows that BBS mice have impaired fear memory, which is partially rescued by lithium treatment.

This study shows that intestinal microbiota modulates epinephrine storage and secretion in adrenal chromaffin cells via Nod1 sensing of bacterial ligands during stress.

This study determines the protonation states of SARS-CoV-2 main protease using neutron crystallography, revealing a zwitterionic active site with specific charge states of key residues.

This paper introduces statistical measures for spatial rotations and projection directions in cryoEM, accounting for molecular symmetry, and implements them in an open-source Python package.

This study identifies oxidative phosphorylation as a driver of treatment failure in recurrent HPV-related head and neck cancer, highlighting Nrf2 as a therapeutic target.

This study examines the temporal metabolic and transcriptomic changes in islets and liver of mice on high-fat diet, revealing dynamic pathophysiology and interorgan crosstalk in diabetes.

This study investigates WSSV infection in wild crustaceans in the Bohai Sea, finding high prevalence rates and confirming infection through electron microscopy.

This paper develops a lentiviral vector for β-thalassemia treatment that restores β-globin expression in Chinese patients with minimal tumorigenesis risk.

This study shows heparan sulfate aids SARS-CoV-2 entry and identifies drugs that inhibit this process in vitro.

This study shows SARS-CoV-2 activates human plasmacytoid pre-dendritic cells (pDC) via UNC93B and IRAK4, leading to interferon and cytokine production.