Author

C. R. Langelier

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 2

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:cell-cell communication· 2 Approach:deep learning· 2 Assay:flow cytometry· 2

Frequent Co-Authors

C. S. Calfee· 3 shared D. J. Erle· 3 shared M. F. Krummel· 3 shared P. G. Woodruff· 3 shared A. J. Combes· 2 shared A. Sil· 2 shared C. M. Hendrickson· 2 shared G. K. Fragiadakis· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersImmunology

C. S. Calfee

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Simultaneous detection of pathogens and antimicrobial resistance genes with the open source, cloud-based, CZ ID pipeline

D. Lu, K. L. Kalantar, V. T. Chu, A. L. Glascock, E. S. Guerrero, N. Bernick, X. Butcher, K. Ewing, E. Fahsbender, O. Holmes, E. Hoops, A. E. Jones, R. Lim, S. McCanny, L. Reynoso, , C. R. Langelier

The paper develops an open-source, cloud-based tool for detecting pathogens and antimicrobial resistance genes in metagenomic and whole-genome sequencing data, demonstrating its application across clinical and environmental studies.

bioRxiv · Apr 12, 2024 · PreprintMicrobiology

Integrated longitudinal multi-omics study identifies immune programs associated with COVID-19 severity and mortality in 1152 hospitalized participants

J. P. Gygi, C. Maguire, R. K. Patel, P. Shinde, A. Konstorum, C. P. Shannon, L. Xu, A. Hoch, N. Jayavelu, IMPACC Network, E. K. Haddad, E. F. Reed, M. Kraft, G. A. McComsey, J. Metcalf, , Pete

This study identifies immune programs linked to COVID-19 severity and mortality through longitudinal multi-omics analysis of 1,152 hospitalized patients.

bioRxiv · Nov 3, 2023Immunology

Immediate myeloid depot for SARS-CoV-2 in the human lung

M. Magnen, R. You, A. A. Rao, R. T. Davis, L. Rodriguez, C. R. Simoneau, L. Hysenaj, K. H. Hu, The UCSF COMET Consortium, C. Love, P. G. Woodruff, D. J. Erle, C. M. Hendrickson, C. S. Calfee, M. A. Matthay, , M. R. Looney

The paper investigates early SARS-CoV-2 infection in human lung myeloid cells, finding rapid viral tropism, ACE2 dependence, and poor interferon induction, suggesting a myeloid depot for viral persistence.

bioRxiv · Apr 28, 2022Immunology

A conserved immune trajectory of recovery in hospitalized COVID-19 patients

T. L. H. Okholm, C. E. Burnett, I. Tenvooren, D. M. Marquez, S. Tamaki, P. M. Sandoval, The UCSF COMET Consortium, C. S. Calfee, C. M. Hendrickson, K. N. Kangelaris, C. R. Langelier, M. F. Krummel, P. G. Woodruff, D. J. Erle, K. M. Ansel, M. H. Spitzer

The paper identifies a conserved immune recovery trajectory in hospitalized COVID-19 patients through longitudinal mass cytometry analysis, linking immune processes to clinical outcomes.

bioRxiv · Mar 15, 2022 · PreprintImmunology

SARS-CoV-2 infection studies in lung organoids identify TSPAN8 as novel mediator

L. Hysenaj, S. Little, K. R. Kulhanek, O. Gbenedio, L. Rodriguez, A. Shen, J.-C. Lone, L. C. Lupin-Jimenez, L. Bonser, N. K. Serwas, K. Bahl, E. Mick, J. Z. Li, V. Ding, S. Matsumoto, , J. P. Roose

The paper identifies TSPAN8 as a novel mediator of SARS-CoV-2 infection in lung organoids, showing its correlation with infection rates and susceptibility to blocking antibodies.

bioRxiv · Jun 1, 2021 · PreprintMicrobiology

Longitudinal single-cell epitope and RNA-sequencing reveals the immunological impact of type 1 interferon autoantibodies in critical COVID-19

M. G. P. van der Wijst, S. E. Vazquez, G. C. Hartoularos, P. Bastard, T. Grant, R. Bueno, D. S. Lee, J. R. Greenland, Y. Sun, R. Perez, A. Ogorodnikov, A. Ward, S. A. Mann, K. L. Lynch, C. Yun, , C. R. Langelier

The paper examines IFN-I autoantibodies in critical COVID-19 patients through longitudinal single-cell analysis, revealing suppressed ISG-I responses in myeloid cells.

bioRxiv · Mar 9, 2021 · PreprintImmunology