R. Kumar

Glucosylhydroxyceramides Modulate Secretion Machinery of a Subset of Plasmodesmata Proteins and a Change in the Callose Accumulation

This study shows that changes in glucosylhydroxyceramides affect callose accumulation by disrupting the secretory machinery of GPI-anchored PD proteins.

Comparative Genomic Analysis of Rapidly Evolving SARS-CoV-2 Viruses Reveal Mosaic Pattern of Phylogeographical Distribution

This study analyzes SARS-CoV-2 genomes from global isolates to reveal mosaic phylogeographical patterns and identify unique mutations associated with immune evasion mechanisms.

Physical confinement impacts cellular phenotype within living materials

The paper investigates how physical confinement in hydrogels affects yeast cell phenotype, finding that hydrogel composition alters cell size, growth patterns, and colony behavior.

Nitrogen starvation and stationary phase lipophagy have distinct molecular mechanisms

This study identifies distinct molecular mechanisms for nitrogen starvation and stationary phase lipophagy in yeast using genetic mutants and functional assays.

Antibacterial efficacy of Jackfruit rag extract against clinically important pathogens and validation of its antimicrobial activity in Shigella dysenteriae infected Drosophila melanogaster infection model

Differential modulation of heat inducible genes across diverse genotypes and molecular cloning of a sHSP from Pearl millet

The paper profiles heat shock gene transcripts in Pearl millet genotypes under heat stress and clones a sHSP gene from a thermotolerant line, showing transcript expression as a useful screening tool for heat tolerance.

Identification of radiation responsive proteins from Spleen and Intestine tissue of mice using Mass Spectrometry approach.

The paper identifies radiation-responsive proteins in mouse spleen and intestine using mass spectrometry and assesses Podophyllotoxin's protective effect against radiation injury.

Isolation and characterization of bovine herpes virus 5 (BHV5) from cattle in India

The paper reports the first isolation of BHV5 from aborted cattle in India and confirms its identity through molecular and serological methods.

A novel cross talk of AtRAV1, an ethylene responsive transcription factor with MAP kinases imparts broad spectrum disease resistance in plants

This study identifies AtRAV1 as a transcription factor that interacts with MAP kinases to enhance disease resistance in Arabidopsis and tomato.

Conversion of a defensive toxin-antitoxin system into an offensive T6SS effector in Burkholderia

The paper shows Burkholderia converts defensive toxin-antitoxin systems into offensive T6SS effectors to kill co-habiting bacteria.

Coding and noncoding somatic mutations in basal cell carcinoma

This study examines mutations in coding and noncoding regions of genes and promoters in BCC tumors, finding significant associations between specific mutations and clinical features.

Naturally Occurring Shorter and Tumor-associated Mutant RNF167 Variants Facilitates Lysosomal Exocytosis and Plasma Membrane Resealing

This study identifies RNF167 and its variants as regulators of lysosomal exocytosis and plasma membrane resealing, with implications for tumor progression.

TLR3 Deficiency Leads to Altered Immune Responses to Chlamydia trachomatis Infection in Human Oviduct Epithelial Cells

This study shows that TLR3 deficiency in human oviduct epithelial cells alters immune responses to Chlamydia trachomatis infection, increasing inflammation and pathogenesis markers.

Sustained exposure to trypsin causes cells to transition into a state of reversible stemness that is amenable to transdifferentiation

This paper shows that sustained trypsin exposure induces cells to transition into a reversible stem-like state, enabling transdifferentiation and altering cellular behavior.

Olsenella lakotia SW165 sp. nov., an acetate producing obligate anaerobe with a GC rich genome

The paper describes the isolation and characterization of a novel Olsenella species, Olsenella lakotia, from feral chickens, highlighting its unique genomic and metabolic features.

Preclinical immunoPET imaging of glioblastoma-infiltrating myeloid cells using Zirconium-89-labeled anti-CD11b antibody

This paper evaluates 89Zr-labeled anti-CD11b antibody for non-invasive immunoPET imaging of TAMCs in a glioblastoma mouse model, showing specific tumor uptake and validating CD11b expression.

Nuclear deformation and anchorage defect induced by DCM mutants in lamin A

This study examines how DCM-causing lamin A mutants affect nuclear deformation and anchorage under mechanical stress.

Complex responses to inflammatory oxidants by the probiotic bacterium Lactobacillus reuteri

This study examines how Lactobacillus reuteri responds to inflammatory oxidants like H2O2 and HOCl, identifying unique resistance mechanisms that could inform microbiota-targeted therapies for gut inflammation.

Doubled haploid based parental lines are most suitable in predicting heterosis using microsatellites and in development of highly heterotic F1 hybrids in Brassica oleracea

The paper identifies superior heterotic crosses in Brassica oleracea using doubled haploid lines and microsatellite markers to predict heterosis and develop high-yielding F1 hybrids.

TLR3 deficiency exacerbates the loss of epithelial barrier function during genital tract Chlamydia muridarum infection

This study shows that TLR3 deficiency worsens epithelial barrier loss in genital tract Chlamydia muridarum infection, as measured by transepithelial resistance and tight-junction gene expression.

Translational initiation factor eIF5 replaces eIF1 on the 40S ribosomal subunit to promote start-codon recognition

The paper presents a cryo-EM structure of a 48S pre-initiation complex showing eIF5's role in promoting start-codon recognition by stabilizing the Met-tRNAi-codon interaction.

Modified protocol for quick and large-scale transformation of Pichia pastoris

The paper describes a modified protocol for transforming Pichia pastoris that eliminates the need for pre-culture growth, allowing faster and more efficient large-scale transformations.

Genome sequence and description of Blautia brookingsii str SG772 nov., a new species of anaerobic bacterium isolated from healthy human gut

The paper describes a new Blautia species, Blautia brookingsii, isolated from the human gut, based on genomic and phenotypic analyses showing significant genomic and functional differences from related species.

Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors

The paper identifies chromothripsis and chromoanasynthesis in tumors with DNA repair deficiencies and links them to MYC/MYCN amplification and therapeutic opportunities.

Neotrygon indica sp. nov., the Indian-Ocean blue spotted maskray (Myliobatoidei, Dasyatidae)

The paper describes a new species of maskray, Neotrygon indica, from the Indian Ocean, based on genetic and morphological analysis of previously identified lineages.

NAC-NOR mutations in tomato Penjar accessions attenuate multiple metabolic processes and prolong the fruit shelf life

This study identifies NAC-NOR mutations in tomato Penjar accessions that reduce respiration, alter cuticle composition, and increase ABA and sucrose levels, leading to prolonged fruit shelf life.