R. Kumar

hnRNPA1 regulates early translation to replication switch in SARS-CoV-2 life cycle

This study shows that SARS-CoV-2 RNA methylation, mediated by hnRNPA1, regulates the switch from translation to replication in the viral life cycle.

A bacterial derived plant- mimicking cytokinin hormone regulates social behaviour in a rice pathogen

This study identifies a bacterial cytokinin hormone produced by Xoo that regulates planktonic lifestyle and virulence in rice pathogens.

Effect of artificial light at night on sleep and metabolism in weaver birds

This study examines the effects of artificial light at night on sleep and metabolism in baya weavers, finding acute exposure causes more pronounced behavioral and physiological changes.

Single cell multi-omics analysis of chromothriptic medulloblastoma highlights genomic and transcriptomic consequences of genome instability

This study analyzes single-cell multi-omics data from medulloblastoma to explore genomic and transcriptomic impacts of chromothripsis and its subclonal variation.

Mapping QTLs for phenotypic and morpho-physiological traits related to grain yield under late sown conditions in wheat (Triticum aestivum L.)

This study maps QTLs for grain yield and related traits under normal and late sown conditions in wheat, identifying a major QTL on chromosome 3B associated with heat tolerance.

Aggregation state of Mycobacterium tuberculosis impacts host immunity and augments pulmonary disease pathology

This study shows that aggregated Mycobacterium tuberculosis causes more severe lung disease in rabbits by increasing bacterial growth and inflammation compared to single-cell infections.

High-density spinal cord stimulation selectively activates lower urinary tract afferents

This study shows that high-density spinal cord stimulation in cats selectively activates lower urinary tract afferents through organized sensory pathways.

A synergistic interaction between HDAC- and PARP inhibitors in childhood tumors with chromothripsis

The paper identifies a synergistic effect between HDAC and PARP inhibitors in childhood tumors with chromothripsis, validated through drug screening and in vivo models.

Brevibacillin 2V, a novel antimicrobial lipopeptide with an exceptional low hemolytic activity

This study identifies and characterizes brevibacillin 2V, a novel antimicrobial lipopeptide with low hemolytic activity against eukaryotic cells, showing promise for antibiotic development.

Elicitation of potent serum neutralizing antibody responses in rabbits by immunization with an HIV-1 clade C trimeric Env derived from an Indian elite neutralizer

This study shows that immunization with a thermostable HIV-1 clade C Env trimer induces potent autologous neutralizing antibodies in rabbits, with distinct epitope specificity compared to natural infection.

α1-COP delivers sphingolipid modifiers and controls plasmodesmal callose deposition in Arabidopsis

The paper identifies α1-COP as a negative regulator of callose accumulation by modulating sphingolipid enzyme translocation in Arabidopsis.

Effect of Pre-harvest Calcium Chloride and Salicylic Acid Spray on Morphological and Biochemical Traits of Guava (Psidium guajava)

This study evaluates the effects of pre-harvest CaCl2 and SA sprays on guava traits, finding that their combination improves fruit quality and yield more than either treatment alone.

Fiber-associated Lachnospiraceae reduce colon tumorigenesis by modulation of the tumor-immune microenvironment

The paper shows that Lachnospiraceae-type gut microbiomes reduce colon tumorigenesis by modulating the tumor-immune microenvironment.

Synthesis, Physiochemical and Biological evaluation of Inclusion Complex of Benzyl Isothiocyanate encapsulated in cyclodextrins for triple negative breast cancer

This study evaluates BITC-CD complexes for triple-negative breast cancer treatment, showing enhanced bioavailability and ROS-mediated cell death.

A Drug-free, Self-destruction Strategy to Combat Bacterial Infections by Using the Intrinsically formed Magnetic Nanoparticles in Bacterial Pathogens

This paper demonstrates a drug-free strategy using magnetic nanoparticles formed by bacteria to combat infections, showing significant bacterial reduction with an alternating magnetic field.

Effect of Silicon Application on Leaf mineral Composition of Eucalyptus

This study investigates the effect of silicon application on leaf mineral composition in Eucalyptus, finding significant increases in nitrogen, phosphorus, and potassium content.

Cellular Fitness Phenotypes of Cancer Target Genes from Oncobiology to Cancer Therapeutics

The paper examines fitness dependencies of cancer drug targets across 19 cancer types, finding that some targets are not fitness genes and suggesting drug repurposing opportunities.

MOLECULAR LANDSCAPE OF OLD AGE MELANOMA BY SURVIVAL AND IMMUNOTHERAPY RESPONSE

This study identifies age-specific mutations and transcriptomic changes in melanoma linked to survival and immunotherapy response, showing that certain mutations improve survival in older patients treated with immunotherapy.

Metabolism Control in 3D Printed Living Materials

This study investigates oxygen permeability in 3D printed living materials and demonstrates their application in enhancing ethanol production in brewing.

Zika Virus Infection Prevents Host mRNA Nuclear Export by Disrupting UPF1 Function

This study shows ZIKV infection disrupts UPF1 function, leading to nuclear mRNA accumulation and impaired neural progenitor cell function.

Emetine as an antiviral agent suppresses SARS-CoV-2 replication by inhibiting interaction of viral mRNA with eIF4E: An in vitro study

This study shows emetine inhibits SARS-CoV-2 replication by blocking viral RNA interaction with eIF4E and demonstrates its antiviral activity against SARS-CoV-2 and IBV in vitro.

Impact of regulative noise exposure to biodiesel production due to enhanced lipid droplet production in Saccharomyces cerevisiae: Preliminary results from a laboratory experiment

The paper investigates how regulative noise exposure increases lipid droplet production in Saccharomyces cerevisiae, potentially enhancing biodiesel production.

Characterization of potassium, sodium and their interactions effects in yeasts

The paper benchmarks non-conventional yeasts against S. cerevisiae strains to characterize how K+ and Na+ affect cell/vacuole volumes and metabolic pathways, finding that K+/Na+ interactions can enhance productivity in certain species.

Isolation and characterization of lumpy skin disease virus from cattle in India

This study isolates and characterizes Lumpy Skin Disease Virus (LSDV) from cattle in India, showing it is closely related to Kenyan strains and demonstrating alternative cell lines for virus isolation and propagation.

Supraphysiological testosterone induces ferroptosis and activates NF-kappaB mediated immune pathways in prostate cancer through nucleophagy

Global population genomic analysis of Mycoplasma bovis isolates reveals transcontinental variations and potential virulence genes

This study analyzes the global genomic diversity of Mycoplasma bovis isolates to identify transcontinental transmission patterns and potential virulence genes.

SARS-CoV-2 infects cells following viral entry via clathrin-mediated endocytosis

This study shows SARS-CoV-2 enters cells via clathrin-mediated endocytosis, and inhibiting clathrin reduces viral infectivity.

Comparative Genomics and Integrated Network Approach Unveiled Undirected Phylogeny Patterns, Co-mutational Hotspots, Functional Crosstalk and Regulatory Interactions in SARS-CoV-2

The paper analyzes SARS-CoV-2 genomic variations and host-pathogen interactions to identify mutational patterns, co-mutations, and functional implications in USA strains.

Experimental methodologies can affect pathogenicity of Batrachochytrium salamandrivorans infections

The paper evaluates how variations in experimental methods affect disease-induced mortality in eastern newts infected with Bsal, finding that passage duration, exposure method, and habitat influence outcomes.

Investigation of a night soil compost psychrotrophic bacterium Glutamicibacter arilaitensis LJH19 for its safety, efficient hydrolytic and plant growth-promoting potential