R. Wang

This study shows that RMS tumors express more IR-A than IR-B, and reducing IR-A with SSOs decreases tumor growth by restoring IR-B expression.

The paper identifies host factors and pathways common to SARS-CoV-2 and common cold coronaviruses using CRISPR screens, revealing shared and unique factors that support viral infection.

This study designs engineered proteases that specifically degrade active RAS by cleaving a conserved sequence in switch 2, showing efficacy in vitro and in human cell culture.

The paper investigates how pharmacological and genetic manipulations of Ca2+ signaling affect auxin-regulated PIN trafficking, finding contrasting results between exogenous Ca2+ manipulations and genetic mutants.

This study uses multi-region single-cell sequencing to map the spatial and cellular architecture of early-stage lung adenocarcinoma, revealing geospatial lineage evolution and potential therapeutic targets.

This study analyzes single-cell RNA and TCR profiles from AML patients before and after PD-1 blockade therapy to identify factors influencing response and resistance.

This study shows SARS-CoV-2 uses the SR-B1-mediated HDL uptake pathway alongside ACE2 for entry, and blocking this pathway inhibits infection.

This paper identifies two potent DHODH inhibitors with broad-spectrum antiviral activity against RNA viruses, including SARS-CoV-2, and suggests their potential clinical use.

B cells integrate innate TLR and adaptive CD40 signals to induce BATF3 transcription factor for production of IL-27, which together with INFg optimizes antibody responses.

The paper introduces a network-based algorithm to estimate ecosystem resilience using palaeoecological data, identifying increasing diatom community instability during eutrophication in modelled and empirical data.

This study shows that the JE vaccine SA14-14-2 protects mice against ZIKV through cross-reactive T cell immunity rather than antibodies.

This study examines layer-specific retinal vascular reactivity in diabetic patients and finds impaired responses to oxygen and carbon dioxide in deep retinal layers.

This study shows that polyamine homeostasis in T cells is regulated by de novo synthesis and salvage pathways, affecting proliferation and function, with implications for inflammatory and autoimmune diseases.

The paper links plant spectral variation to ecosystem productivity by analyzing spectral and resource-use complementarity in grassland and forest communities.

This study identifies and characterizes ZmCPAs in maize, showing their roles in salt tolerance through expression analysis and functional validation.

The paper designs optimized HCV E2 glycoproteins to enhance binding and cross-neutralization by modifying antigenic sites and testing immunogenicity in mice.

This study identifies pathogenic Escherichia coli isolates from donkey foals' diarrhea in Northern China, revealing virulence factors, antibiotic resistance, and genomic features.

This paper identifies elasnin as a potent antibiofilm agent that inhibits mono- and multi-species biofilms with low toxicity and resistance risk.

This study isolates and characterizes 206 RBD-specific monoclonal antibodies from SARS-CoV-2 infected individuals, finding diverse neutralizing activity and species-specific antibody responses.

NAD+ supplementation enhances T cell activation and tumor-killing capacity in immunotherapies.

This study develops an AI system to identify fetal nucleated red blood cells using deep learning, achieving high accuracy and sensitivity in testing.

This paper identifies dynamic metabolic reprogramming in dendritic cells during influenza infection, showing it is essential for effector function and immune response initiation.

This study shows auxin promotes PtoDC3000 pathogenesis by suppressing host defenses and directly regulating bacterial virulence gene expression.

Dietary restriction alters sulfhydrated protein enrichment and downstream pathways in multiple tissues, partly dependent on cystathionine γ-lyase.

This study investigates the role of the dorsal premotor cortex (PMd) in hand gesture preparation in macaques, finding that some neurons are involved in hand shape preparation regardless of visual stimuli or selection strategies.

The paper presents a large multi-omic cohort of 2,183 adults to identify correlations between gut microbiome features and various health-related factors, validated in an additional cohort.

This study identifies hsa_circ_0001947 as a tumor suppressor in AML that inhibits cell proliferation and drug resistance by sponging hsa-miR-329-5p and regulating CREBRF expression.

This study shows that effector T cells use inosine as an alternative carbon source under glucose restriction, enhancing anti-tumor function and bypassing tumor-imposed metabolic limitations.