R. Wang

This study identifies rhizosphere metabolites and microbial shifts in alfalfa soils under continuous cropping, showing autotoxic substances like p-coumaric acid contribute to crop obstacles.

This study develops a subunit nanovaccine using polymersomes decorated with SARS-CoV-2 RBD, showing enhanced neutralizing antibody and T cell responses in mice.

This study uses iPSC-derived airway cells to model SARS-CoV-2 infection, showing multiciliated cells as primary targets and demonstrating antiviral responses to remdesivir and camostat methylate.

This study shows ARID1A loss activates HERVH, which promotes tumor growth by modulating BRD4-dependent transcription in colorectal cancer.

This study designs artezomibs, artemisinin-proteasome inhibitor hybrids, which overcome resistance in Plasmodium falciparum by targeting proteasomes, including those with mutations.

This paper demonstrates that conjugating the SARS-CoV-2 Spike protein to a polymeric glyco-adjuvant elicits strong cellular and humoral immune responses in mice.

This paper presents a deformable microfluidic device using microbeads to separate plasma and retrieve blood cells, supported by imaging and computational modeling.

This study identifies a novel role of low barrier hydrogen bonds in promoting selective tubulin degradation through small molecule interactions.

The paper shows liver endothelial cells promote HER3-mediated survival in KRAS wild-type and mutant colorectal cancer cells through secreted factors, suggesting HER3 as a therapeutic target regardless of KRAS mutation status.

This study identifies EtfDMtb as an essential dehydrogenase for fatty acid β-oxidation in Mtb, showing that disrupting it kills the bacterium in vitro and in mice.

This study identifies high-frequency SARS-CoV-2 mutations that may compromise multiple monoclonal antibody therapies in clinical trials using a topology-based deep learning approach.

This paper demonstrates that non-T-cell based antigen depletion can induce apoptosis in CD19-expressing cancer cells, proposing a universal cellular therapy strategy using artificial antigen-recognizing cells.

This study shows that matrix stiffness affects intestinal stem cell fate by reducing Lgr5high ISCs and promoting differentiation into goblet cells, mediated by YAP nuclear translocation.

This study shows that a bacteriophage inhibits murine norovirus replication in RAW 264.7 cells through activation of innate immune responses and guanylate binding proteins.

This study demonstrates that boron-doped bismuth oxybromide rapidly inactivates SARS-CoV-2 under visible light and in the dark, outperforming conventional photocatalysts.

This study evaluates antibody resistance and ACE2 usage in SARS-CoV-2 variants, finding SA501Y.V2 shows the highest resistance and expanded host range.

This study identifies and characterizes two divergent CCR subfamilies in Brassica napus, revealing their distinct roles in lignin biosynthesis, phenylpropanoid flux, and glucosinolate interactions.

This study shows that apoptotic extracellular vesicles (apoEVs) protect liver homeostasis and regeneration by forming a chimeric organelle with the Golgi apparatus and restoring hepatic ploidy.

This study tracks the global spread of the carbapenem resistance gene blaNDM by analyzing genomic contexts and mobile genetic elements across 6000 bacterial genomes.

This study identifies the ZmCd1 gene controlling cadmium accumulation in maize grains and develops molecular markers for breeding low-Cd maize varieties.

This study shows Tim-3 promotes NF90 ubiquitination and degradation, inhibiting antiviral innate immunity via stress granule formation.

This study shows that deleting PHD2 in adipocytes maintains BAT activity at thermoneutrality, increases energy expenditure, and identifies serum PHD2 as a biomarker for metabolic disease.

This paper develops a droplet-based microfluidics platform for high-throughput functional antibody screening, identifying potent cancer immunotherapeutics like CD40 agonists and anti-Her2/anti-CD3 bispecific antibodies.

This study shows that wild-type IDH1 is a metabolic target in pancreatic cancer cells under nutrient limitation, and FDA-approved drugs can inhibit it effectively in preclinical models.

This paper develops a pyrF-based genetic manipulation system for Acinetobacter baumannii, enabling efficient marker-less gene editing in multiple strains.

This study shows SNAI1 represses let-7 miRNA, promoting stemness in cancer cells, and demonstrates nanoparticle-mediated SNAI1 knockdown reduces tumor burden.

This study develops an in vivo optical imaging method to quantify long-chain fatty acid uptake in breast cancer models, showing reduced uptake with MYC downregulation and increased uptake with tumor aggressiveness.

This study uses TRACE-seq to analyze single throat swabs, integrating SARS-CoV-2 genome, microbiome, antibiotic resistance, and host response data.

This study reports cryo-EM structures of potent SARS-CoV-2 neutralizing antibodies, revealing bivalent binding mechanisms and their correlation with enhanced neutralization and S1 subunit shedding.