Author

N. Fan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Cell Biology· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell type annotation· 5 Organism:mouse· 4 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:clustering· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

A. Gopalan· 2 shared C. Sawyers· 2 shared E. De Stanchina· 2 shared H. Li· 2 shared H. Zhao· 2 shared J. Tang· 2 shared K. M. Todorova· 2 shared W. Kang· 2 shared

Activity by Year

2022-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCancer Biology

A. Gopalan

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

The neuroendocrine transition in prostate cancer is dynamic and dependent on ASCL1

R. Romero, T. Chu, T. J. Gonzalez-Robles, P. Smith, Y. Xie, H. Kaur, S. Yoder, H. Zhao, C. Mao, W. Kang, M. Pulina, K. E. Lawrence, A. Gopalan, S. Zaidi, K. Yoo, , C. Sawyers

This study identifies ASCL1 as a critical driver of neuroendocrine lineage transition in prostate cancer using an in vivo model and spatial transcriptomics.

bioRxiv · Apr 9, 2024Cancer Biology

Tumorigenesis driven by the BRAF V600E oncoprotein requires secondary mutations that overcome its feedback inhibition of migration and invasion

s. gadal, J. A. Boyer, S. F. Roy, N. A. Outmezguine, M. Sharma, H. Li, N. Fan, E. Chan, Y. Romin, A. Barlas, Q. Chang, P. Pancholi, N. M. Timaul, M. Overholtzer, R. Yaeger, , N. Rosen

This study shows that BRAFV600E mutations inhibit cell migration and invasion through feedback inhibition of RAC1, requiring secondary mutations to overcome this block and enable tumorigenesis.

bioRxiv · Nov 21, 2023 · PreprintCancer Biology

ERG activates a stem-like proliferation-differentiation program in prostate epithelial cells with mixed basal-luminal identity

W. Feng, E. Ladewig, N. Salsabeel, H. Zhao, Y. S. Lee, A. Gopalan, M. Lange, H. Luo, W. Kang, N. Fan, E. Rosiek, E. De Stanchina, Y. Chen, B. S. Carver, C. S. Leslie, C. Sawyers

The paper identifies a stem-like proliferative state in prostate epithelial cells driven by ERG activation, which transitions to luminal cells and is associated with specific chromatin states.

bioRxiv · May 15, 2023Cancer Biology

A Chitin-Binding Protein Ultra-highly expressed in the Outer Fold of Mantle is Related to Shell Colour in Pacific Oyster Crassostrea gigas

M. Li, J. Tang, B. Huang, Y. Liu, L. Wei, Y. Han, X. Wang, X. Sang, M. Yuan, N. Fan, S. Cai, Y. Zheng, M. Zhang, X. Wang

This study identifies a chitin-binding protein, CgCBP, highly expressed in the outer fold of the mantle of Pacific oyster Crassostrea gigas, which is linked to shell pigmentation through its role in periostracum structure.

bioRxiv · Apr 18, 2022 · PreprintPhysiology

PSMA-bearing extracellular vesicles secreted from prostate cancer convert the microenvironment to a tumor-supporting, pro-angiogenic state.

C. M. Machado, M. Skubal, K. Haedicke, F. S. Pittela, E. P. Stater, B. M. Larney, T. L. A. O. Silva, E. T. Costa, C. Masotti, A. H. Otake, L. N. S. Andrade, M. S. Junqueira, H.-T. Hsu, S. Das, E. C. Pratt, , J. Grimm

The paper shows that PSMA-bearing extracellular vesicles from prostate cancer cells promote a pro-angiogenic tumor microenvironment by increasing VEGF-A, angiogenin, and 4EBP-1 phosphorylation.

bioRxiv · Feb 25, 2022 · PreprintCancer Biology

Generating Functional Cells Through Enhanced Interspecies Chimerism with Human Pluripotent Stem Cells

G. Pan, L. Lai, Y. Zhu, Z. Zhang, N. Fan, K. Huang, H. Li, J. Gu, Q. Zhang, Z. Ouyang, T. Zhang, J. Tang, Y. Zhang, Y. Suo, C. Lai, , T. Zhou

This study demonstrates that MYCN and BCL2 enhance interspecies chimerism with human pluripotent stem cells, enabling the generation of functional human blood progenitor cells in chimeric embryos.

bioRxiv · Feb 10, 2022Cell Biology

Covalent inhibition of endoplasmic reticulum chaperone GRP78 disconnects the transduction of ER stress signals to inflammation and lipid accumulation in diet-induced obese mice

J. Rong, D. Luo, N. Fan, X. Zhang, F. Y. Ngo, J. Zhao, W. Zhao, M. Huang, D. Li, Y. Wang

eLife · Feb 9, 2022Peer-reviewedPharmacology & Toxicology