Author

R. Houston

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 1 Ecology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:ecology & biodiversity· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

S. Sekine· 3 shared Y. Sekine· 3 shared D. P. Narendra· 2 shared A. Dunbar· 1 shared A. GALMAN· 1 shared A. HAMPE· 1 shared A. J. Nelson· 1 shared A. Karzai· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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3 shared papersCell Biology

S. Sekine

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Decomposing drivers in avian insectivory: large-scale effects of climate, habitat and bird diversity

L. SCHILLE, E. VALDES-CORRECHER, F. ARCHAUX, F. BALACENOIU, M. C. BJOERN, M. BOGDZIEWICZ, T. BOIVIN, M. BRANCO, T. DAMESTOY, M. DE GROOT, J. DOBROSAVLJEVIC, M.-L. DUDUMAN, A.-M. DULAURENT, S. GREEN, J. GRUNWALD, , MUSOLIN

The paper investigates how climate, habitat, and bird diversity influence avian insectivory across Europe, finding that bird predation is affected by climate and habitat independently of bird diversity.

bioRxiv · Jan 19, 2023Ecology

Jak2V617F Reversible Activation Shows an Essential Requirement for Jak2V617F in Myeloproliferative Neoplasms

A. Dunbar, R. L. Bowman, Y. Park, F. Izzo, R. M. Myers, A. Karzai, W. Jun Kim, I. Fernandez Maestre, M. R. Waarts, A. Nazir, W. Xiao, M. Brodsky, M. Farina, L. Cai, S. F. Cai, , R. L. Levine

This study shows that reversible activation of Jak2V617F in a mouse model demonstrates its essential role in myeloproliferative neoplasms and highlights the therapeutic potential of mutant-specific JAK2 inhibition.

bioRxiv · May 18, 2022 · PreprintCancer Biology

A mitochondrial iron-sensing pathway regulated by DELE1

Y. Sekine, R. Houston, E. Fessler, L. T. Jae, D. P. Narendra, S. Sekine

This study identifies DELE1 as a mitochondrial protein whose import and stability are regulated by iron availability, linking mitochondrial function to the heme-regulated kinase HRI-mediated stress response.

bioRxiv · Apr 14, 2022 · PreprintCell Biology

Discovery of bactericides as an acute mitochondrial membrane damage inducer

R. Houston, Y. Sekine, M. B. Larsen, K. Murakami, D. P. Narendra, B. B. Chen, S. Sekine

The paper identifies Chlorhexidine and Alexidine as bactericides that induce acute mitochondrial membrane damage by altering inner mitochondrial membrane integrity and evoking a unique stress response.

bioRxiv · Apr 9, 2021Cell Biology

Acetylation-mediated phase control of the nucleolus regulates cellular acetyl-CoA responses

R. Houston, S. Sekine, M. J. Calderon, F. Seifuddin, G. Wang, H. Kawagishi, D. A. Malide, Y. Li, M. Gucek, M. Pirooznia, A. J. Nelson, M. P. Stokes, J. Stewart-Ornstein, S. G. Wendell, S. C. Watkins, , Y. Sekine

The paper shows that acetyl-CoA depletion disrupts nucleolar integrity, activates p53 via ribosomal proteins, and is mediated by class IIa HDACs regulating nucleolar phase state.

bioRxiv · Jan 24, 2020Cell Biology