Author

S. Hayashi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biophysics· 2 Bioengineering· 1 Ecology· 1 Evolutionary Biology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Approach:statistical model· 5 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Y. Tanaka· 3 shared A. S. Perelson· 2 shared D. Fujinami· 2 shared D. Kohda· 2 shared K. Aihara· 2 shared K. Kitagawa· 2 shared K. Watashi· 2 shared L. Allweiss· 2 shared

Activity by Year

2020-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersMicrobiology

Y. Tanaka

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

NEDD4-binding protein 1 suppresses HBV replication by degrading HBV RNAs

N. Kobayashi, S. Suzuki, Y. Sakamoto, R. Suzuki, K. Mori, Y. Kosugi, L. Liang, T. Saito, T. Izumi, K. Noda, D. Okuzaki, Y. Kanegae, S. Hayashi, Y. Tanaka, Y. Matsuura, , T. Fukuhara

This paper identifies N4BP1 as a host factor that suppresses HBV replication by degrading HBV RNAs, with its KH-like and RNase domains required for this effect.

bioRxiv · Oct 6, 2023 · PreprintMicrobiology

Surface-engineered extracellular vesicles to modulate antigen-specific T cell expansion for cancer immunotherapy

X. Lyu, T. Yamano, S. Imai, T. V. Le, D. Bolidong, M. Ueda, S. Warashina, H. Mukai, S. Hayashi, K. Matoba, T. Nishino, R. Hanayama

The paper develops antigen-presenting extracellular vesicles (AP-EVs) engineered to enhance T cell expansion and anticancer immunity through combined immunotherapy.

bioRxiv · Sep 25, 2023 · PreprintBioengineering

Simple ways to avoid collecting highly 137Cs-contaminated Aralia elata buds

M. Sakai, M. Watanabe, M. Kanao Koshikawa, A. Tanaka, A. Takahashi, S. Takechi, M. Takagi, T. Tsuji, H. Tsuji, T. Takeda, J. Jo, M. Tamaoki, S. Hayashi

The paper evaluates environmental factors affecting 137Cs contamination in Aralia elata buds to provide strategies for avoiding highly contaminated specimens.

bioRxiv · Sep 18, 2023 · PreprintEcology

Multiscale modeling of HBV infection integrating intra- and intercellular viral propagation for analyzing extracellular viral markers

K. Kitagawa, K. Kim, M. Iwamoto, S. Hayashi, H. Park, T. Nishiyama, N. Nakamura, Y. Fujita, S. Nakaoka, K. Aihara, A. S. Perelson, L. Allweiss, M. Dandri, K. Watashi, Y. Tanaka, S. Iwami

This study develops a multiscale mathematical model to predict intrahepatic cccDNA dynamics using serum viral markers, offering a non-invasive method for HBV infection analysis.

bioRxiv · Jun 6, 2023 · PreprintMicrobiology

A multi-omic Nicotiana benthamiana resource for fundamental research and biotechnology

B. Ranawaka, J. An, M. Lorenc, H. Jung, M. Sulli, G. Aprea, S. Roden, S. Hayashi, T. Cooper, Z. LeBlanc, V. Llaca, D. Orzaez, A. Bombarely, J. Bally, C. Winefield, , P. M. Waterhouse

The paper provides high-quality genome assemblies and multi-omic datasets for Nicotiana benthamiana strains LAB and QLD, along with SNP mapping, to enhance their use in research and biotechnology.

bioRxiv · Dec 30, 2022 · PreprintPlant Biology

Prediction of elimination of intrahepatic cccDNA in hepatitis B virus-infected patients by a combination of noninvasive viral markers

S. Iwami, M. Iwamoto, T. Wakita, K. Watashi, A. S. Perelson, Y. Tanaka, M. Dandri, K. Aihara, M. Muramatsu, S. Iwami, E. Kawakami, L. Allweiss, P. Tangkijvanich, N. Chuaypen, M. Atsukawa, , Y. Fujita

This study develops a noninvasive method using viral markers to predict cccDNA levels in HBV patients, validated against liver biopsy data.

bioRxiv · Nov 4, 2022 · PreprintMicrobiology

Residue-based correlation between equilibrium and rate constants is an experimental formulation of the consistency principle for smooth structural changes of proteins

D. Kohda, S. Hayashi, D. Fujinami

The paper formulates the consistency principle as a quadratic relationship between residue-specific equilibrium and rate constants, providing an experimental method to verify smooth protein folding.

bioRxiv · Oct 24, 2022Biophysics

Microbial mat compositions and localization patterns explain the virulence of black band disease in corals

N. Wada, A. Iguchi, Y. Urabe, Y. Yoshioka, N. Abe, K. Takase, S. Hayashi, S. Kawanabe, Y. Sato, S.-L. Tang, N. Mano

This study shows that microbial composition and spatial distribution in black band disease coral mats correlate with disease migration rates and virulence.

bioRxiv · Oct 4, 2022 · PreprintMicrobiology

Deviation from the Residue-Based Linear Free Energy Relationship Reveals a Non-Native Structure in Protein Folding

D. Fujinami, S. Hayashi, D. Kohda

The paper examines the residue-based linear free energy relationship (rbLFER) in protein folding and finds deviations from linearity indicate non-native structures in transition states.

bioRxiv · Jan 7, 2022Biophysics

Variation and process of life history evolution in insular dwarfism as revealed by a natural experiment

S. Hayashi, M. O. Kubo, M. R. Sanchez-Villagra, H. Taruno, M. Izawa, T. Shiroma, T. Nakano, M. Fujita

The paper investigates life history evolution in insular dwarfism using deer populations, finding slower growth and delayed maturity in more isolated populations.

bioRxiv · Dec 23, 2020 · PreprintEvolutionary Biology