T. Shioda

An engineered ACE2 decoy broadly neutralizes Omicron subvariants and shows therapeutic effect in SARS-CoV-2-infected cynomolgus macaques

This paper shows an engineered ACE2 decoy neutralizes Omicron subvariants and is effective in treating SARS-CoV-2 infection in macaques.

IFNA pathway drives the more aggressive phenotype of KRASG12D-mutant pancreatic ductal adenocarcinomas via IFNAR1/STAT3 activation

The paper shows that the IFNA pathway promotes aggressive KRASG12D-mutant pancreatic ductal adenocarcinomas through IFNAR1/STAT3 activation and identifies IFNAR1 inhibition as a potential therapeutic strategy.

Identification, crystallization and epitope determination of public TCR shared and expanded in COVID-19 patients

The paper identifies and crystallizes public TCRs from SARS-CoV-2-specific Tfh cells in COVID-19 patients, showing they recognize conserved spike epitopes and cross-react with symbiotic bacteria.

An infectivity-enhancing site on the SARS-CoV-2 spike protein is targeted by COVID-19 patient antibodies

This study identifies an NTD site on SARS-CoV-2 spike protein that enhances infectivity when targeted by antibodies, and finds these antibodies are present in hospitalized patients and some uninfected donors.

Antibody-dependent enhancement representing in vitro infective progeny virus titer correlates with the viremia level in dengue patients

The paper examines the correlation between in vitro ADE activity and in vivo viremia levels in dengue patients, finding a positive correlation between ADE activity and viral load.

The N-terminal domain of spike glycoprotein mediates SARS-CoV-2 infection by associating with L-SIGN and DC-SIGN

This study identifies L-SIGN and DC-SIGN as receptors for the N-terminal domain of SARS-CoV-2 spike protein, showing their role in infection and the importance of anti-NTD antibodies.

Preclinical study of DNA vaccines targeting SARS-CoV-2

This study evaluates a DNA vaccine targeting SARS-CoV-2 Spike protein, showing enhanced humoral and cellular immune responses and neutralizing antibody activity.