O. Chaudhuri

Crosslinker Architectures Impact Viscoelasticity in Dynamic Covalent Hydrogels

This study investigates how different crosslinker architectures affect the viscoelastic properties of dynamic covalent hydrogels, showing that side-chain and telechelic crosslinkers lead to distinct mechanical behaviors.

Dosing and Delivery of Bacteriophage Therapy In a Murine Wound Infection Model

This study evaluates phage therapy dosing and delivery in a mouse wound infection model, finding topical high-dose repeated administration effective and developing a sustained-release hydrogel system.

Stress relaxing granular bioprinting materials enable complex and uniform organoid self-organization

This paper introduces a tunable granular biomaterial, MAGIC matrix, that enables precise control of initial conditions for tissue growth, leading to improved organoid reproducibility and complexity.

Monocytes use protrusive forces to generate migration paths in viscoelastic collagen-based extracellular matrices

This study shows that monocytes migrate through viscoelastic collagen matrices by generating protrusive forces via actin polymerization, with increased matrix stiffness and viscoelasticity enhancing their 3D migration.

Collective invasion of the basement membrane in breast cancer driven by forces from cell volume expansion and local contractility

This study shows breast cancer cells invade the basement membrane using both proteases and mechanical forces from cell volume expansion and local contractility.

Delivery of CAR-T Cells in a Transient Injectable Stimulatory Hydrogel Niche Improves Treatment of Solid Tumors

This paper develops an injectable hydrogel to co-deliver CAR-T cells and cytokines, enhancing solid tumor treatment in mice by creating a transient inflammatory niche.

The nature of mitotic forces in epithelial monolayers

This study identifies two distinct stages of mitotic force generation in epithelial monolayers: protrusive forces driving mitotic elongation and outward forces facilitating post-mitotic re-spreading.

YAP-independent mechanotransduction drives breast cancer progression

This study shows that mechanotransduction in breast cancer occurs without YAP, due to compact nuclear morphologies in vivo.