X. Chen

This study shows that lower shear stress promotes neutrophil extracellular traps (NETs) formation, which worsens atherosclerosis by damaging endothelial cells through Piezo1-mediated mechanosensation.

The paper assesses the protective effect of neutralizing antibodies from prior Omicron BA.5 infection against symptomatic reinfection with BA.5, BF.7, CH.1.1, and XBB.1.5 subvariants, finding a strong correlation between antibody titers and reduced reinfection risk.

This paper develops a deep learning method to assess chondrocyte viability using label-free two-photon microscopy images from rat and porcine cartilage, achieving 95% accuracy.

This study shows TRAF4 is essential for ST2+ memory Th2 cell proliferation in IL-33-driven type 2 airway inflammation, revealing its role in AKT/mTOR and ERK1/2 signaling and gene expression.

This study shows a lupus anti-DNA autoantibody activates cGAS and improves survival in glioblastoma models by enhancing CD8+ T cell infiltration.

The paper develops a potent and selective CDKL5/GSK3 chemical probe and demonstrates its neuroprotective effects in human motor neurons under ER stress.

The paper shows that Hap43, an iron-responsive transcription factor, is degraded under high iron conditions in C. albicans, leading to antioxidant gene activation and enhanced gut colonization.

This study compares multi-omics data across three plant sources of Amomi Fructus to identify genetic and transcriptomic differences, including gene flow and metabolic variation between populations.

This study identifies two types of nucleoli in C. elegans and shows that rRNA processing factors regulate their structure and dynamics.

This study investigates the combined toxicity of aflatoxin B1 and fumonisin B1 on HepG2 cells using respirometry and transcriptome analyses, finding increased mitochondrial inhibition and p53 pathway disruption.

This paper uses RNA sequencing to classify lung cancer subtypes and identifies drug repositioning opportunities based on lineage-specific responses.

The paper identifies two new receptors, Ly6c1 and Car4/CA4, for crossing the blood-brain barrier using AAV vectors and computational modeling.

The paper develops AAV vectors with endothelial-specific tropism for brain delivery in rodents and broad tropism in primates, demonstrating their utility in genetic engineering of the blood-brain barrier.

This paper introduces APPRAISE, a method that rapidly ranks engineered proteins by their receptor binding propensity using structure modeling, demonstrating its accuracy on various protein classes.

This paper develops an AI-assisted stimulated Raman cytology method to detect peritoneal metastasis in gastric cancer with high accuracy and speed.

This study identifies a mechanism by which macrophages induce MenaINV expression in breast cancer cells through cooperative NF-κB and Notch1 signaling, leading to increased metastasis.

This study develops a coevolutionary game model to show how cooperation and risk interact in collective-risk social dilemmas, finding that cooperation can be sustained through specific feedback mechanisms and initial conditions.

Open-3DSIM improves lateral and axial resolution in 3D structured illumination microscopy and offers artifact suppression and defocus elimination across various specimens.

This study shows that PSD condensates mediate actin bundling through phase separation, involving Homer and other scaffolds, and is regulated by CaMKII and Homer1a.

This paper introduces Spatial VDJ, a spatial transcriptomics method that maps T and B cell receptors in human tissue, revealing clonal dynamics and spatial organization of lymphocytes.

This study compares the composition and properties of three mucus types from Cornu aspersum to understand their structure-function relationships and identify novel components.

This study investigates how flow-induced mechanical forces regulate YAP nucleocytoplasmic transport through actin cap formation and nuclear stiffness changes, revealing a unified mechanism linking mechanical stimulation to transcriptional regulation.

The paper introduces an automated feeding system for African killifish to study dietary restriction effects on lifespan and cognitive behavior, showing sex-specific transcriptome changes and extending male lifespan.

This study predicts nasal spray vaccine droplet behavior and immune response in a 6-year-old's nasal cavity to improve COVID-19 prevention.

The paper examines how tidal fluctuations and human disturbances affect microbiota structure and assembly in intertidal groundwater-surface water systems, identifying rhythmic microbial patterns and their environmental drivers.

The paper identifies a proliferative exhausted CD8+ T cell cluster in HPV-positive HNSCC that correlates with better patient survival and suggests potential therapeutic implications.

The paper presents the crystal structure of the Bre1 RBD-Rad6 complex and shows how their interaction activates Rad6 for H2Bub1 catalysis.

This study uses optical metabolic imaging to show diet and sex influence lipid metabolism in aging Drosophila brains, revealing IIS pathway involvement.

The paper identifies a 3-smRC signature from circulating extracellular vesicles that detects early-stage liver cancer with high sensitivity and specificity.