X. Chen

Spatio-temporal variation of bacterial community structure in two intertidal sediment types of Jiaozhou Bay

This study examines bacterial community structure in intertidal sediments of Jiaozhou Bay, finding that sandy sediments have more species involved in community building and that temporal changes have a greater impact on bacterial communities than on gene families.

An intrinsically Disordered RNA Binding Protein Modulates mRNA Translation and Storage

This study investigates how an intrinsically disordered RNA-binding protein modulates mRNA translation and storage through distinct mechanisms involving ribosome movement and post-translational modifications.

PENet: A phenotype encoding network for automatic extraction and representation of morphological discriminative features

PENet is a deep learning model that automatically extracts and encodes morphological features into hash codes, showing effectiveness in feature extraction and image retrieval across beetle datasets.

Living cell mTORC1 inhibition reporter mTIR reveals nutrient-sensing targets of histone deacetylase inhibitor

The paper introduces a genetically encoded mTORC1 inhibition reporter, mTIR, which identifies histone deacetylase inhibitors that selectively target mTORC1 through nutrient-sensing gene expression.

Lactylation-driven FTO-mediated m6A modification of CDK2 aggravates diabetic microvascular anomalies

This study shows that FTO, through lactylation-driven m6A modification of CDK2, worsens diabetic retinopathy by promoting angiogenesis and inflammation, and presents a nanotherapeutic approach to inhibit FTO.

A Novel Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth in Mouse Models of GI Cancer

This paper introduces ADT-007, a novel pan-RAS inhibitor that effectively blocks tumor growth in mouse models of GI cancer by targeting RAS activation and inducing apoptosis.

A high-density lineage tree reveals dynamics of expression differences accumulation in nondifferentiating clonal expansion

The paper develops a method to track transcriptome differences in clonal expansion and shows constrained expression noise dynamics during cell divisions.

Co-engagement of TIGIT+ immune cells to PD-L1+ tumours by a bispecific antibody potentiates T-cell response and tumour control

This paper shows that a bispecific antibody targeting PD-L1 and TIGIT enhances T-cell response and tumor control compared to using the individual antibodies.

The soluble guanylyl cyclase pathway is inhibited to evade androgen deprivation-induced senescence and enable progression to castration resistance

This study identifies the soluble guanylyl cyclase (sGC) pathway as a target for castration-resistant prostate cancer (CRPC) treatment, showing that riociguat inhibits CRPC growth and enhances radiation response.

Bcl-xL is translocated to the nucleus via CtBP2 to epigenetically promote metastasis

This study identifies CtBP2 as a mediator of Bcl-xL nuclear translocation, which promotes metastasis by enhancing H3K4me3 and TGFβ transcription.

The potential of Senicapoc, a KCNN4 inhibitor, for the prevention and treatment of breast cancer

This study investigates Senicapoc, a KCNN4 inhibitor, and finds it delays mammary tumor development and slows tumor growth in mouse models, suggesting potential for breast cancer prevention and treatment.

Metabolic Reprogramming by Histone Deacetylase Inhibition Selectively Targets NRF2-activated tumors.

The paper shows that inhibiting HDACs selectively targets NRF2-activated lung adenocarcinoma by altering chromatin and metabolic pathways.

Context-Aware Deep Learning Enables High-Efficacy Localization of High Concentration Microbubbles for Super-Resolution Ultrasound Localization Microscopy

This paper introduces LOCA-ULM, a deep learning method for ultrasound localization microscopy that improves microbubble detection and localization accuracy in vivo and in silico.

Tuning social interactions' strength drives collective response to light intensity in schooling fish

This study shows that varying light intensity affects social interactions and collective behavior in schooling fish by altering their responses to obstacles and group motion patterns.

Cross regulation in a three-component cell envelope stress signaling system of Brucella

This study identifies three TCS proteins in Brucella ovis that work together to confer resistance to cell envelope stressors and support intracellular replication.

Pan-cancer analysis of the ion permeome reveals functional regulators of glioblastoma aggression

The paper identifies survival-associated ion permeome genes across 29 cancer types and shows their role in glioblastoma aggression through functional experiments.

Maintaining hypoxia environment of subchondral bone alleviates osteoarthritis progression

This study shows that inhibiting subchondral osteoclastogenesis maintains hypoxia in subchondral bone, slowing osteoarthritis progression by stabilizing HIF-1 and reducing cartilage degeneration.

Self-supervised denoising for structured illumination microscopy enables long-term super-resolution live-cell imaging

The paper introduces a self-supervised denoising method for structured illumination microscopy that enables high-quality super-resolution imaging with reduced fluorescence.

The DEAD-box helicase RCF1 plays roles in miRNA biogenesis and RNA splicing in Arabidopsis

This study identifies RCF1 as a key player in miRNA biogenesis and RNA splicing in Arabidopsis by showing its role in pri-miRNA processing and splicing defects in a mutant.

Sox11 is enriched in myogenic progenitors but dispensable for development and regeneration of skeletal muscle.

This study identifies Sox11 as a marker of differentiating muscle satellite cells, showing reduced expression in quiescent and aged cells, but finds it dispensable for muscle development and regeneration.

Widespread PRC barrel proteins play critical roles in archaeal cell division

This study identifies three PRC barrel proteins in Haloferax volcanii essential for archaeal cell division, showing their conservation and role in division across haloarchaea.

The Potential of Low Press and Hypoxia Environment in Assisting Pan-cancer Treatment

This study constructs a pan-cancer prognosis risk model using ADME genes under low press and hypoxia conditions, finding lower risk scores correlate with better survival in 25 cancer types.

Widespread readthrough events in plants reveal unprecedented plasticity of stop codons

The paper identifies widespread stop codon readthrough events in plants and reveals the plasticity of stop codons in encoding amino acids.

HBV rewires liver cancer signaling by altering PP2A complexes

This study identifies how HBV alters PP2A complexes to drive liver cancer signaling, revealing potential therapeutic targets.

Single-molecule acceptor rise time (smART) FRET for nanoscale distance sensitivity

This paper introduces smART FRET, a method that improves distance sensitivity in single-molecule studies by using acceptor rise time, enabling both closer and longer distance measurements with higher precision.

Inhibition mechanism and antiviral activity of an α-ketoamide based SARS-CoV-2 main protease inhibitor

This study identifies RAY1216, a slow-tight SARS-CoV-2 Mpro inhibitor with improved pharmacokinetics and antiviral activity compared to PF-07321332, currently in phase III clinical trials.

Loss of kinase Atg1 increases yeast maintenance energy requirement

This study shows that loss of the kinase Atg1 in yeast increases maintenance energy requirement and accelerates cell death, suggesting autophagy plays a key role in cellular energetics during aging.

Enhanced transmissibility of XBB.1.5 is contributed by both strong ACE2 binding and antibody evasion

This study shows XBB.1.5 has higher ACE2 binding and moderate antibody evasion, contributing to its increased transmissibility compared to other variants.

Keystone taxa responsible for the microbial community stability and performance of activated sludges

The paper identifies keystone taxa in activated sludge microbial communities that enhance stability but reduce function, highlighting the trade-off between stability and performance.

Zero-shot learning enables instant denoising and super-resolution in optical fluorescence microscopy

This paper introduces a zero-shot deep learning method for super-resolution microscopy that enhances resolution with less fluorescence and no training data.