X. Chen

The paper introduces a pneumatic nano-sieve device for capturing and releasing nanoparticles, demonstrating efficient capture with high flow rates and micro-grooves.

This study identifies the N-terminal extension of Arabidopsis AGO1 as essential for miRNA activity, showing its role in miRNA loading and trans-acting siRNA biogenesis.

The paper identifies E6AP AZUL binding to UBQLN1/2 UBA domains, shows phase separation, and presents an integrated AlphaFold-NMR structure.

This paper introduces CS Doppler, a contrast-free super-resolution Doppler technique using deep generative networks, achieving improved spatial resolution and real-time imaging in vivo.

The paper shows that leukemic cells activate LTβR signaling in mesenchymal stem cells, suppressing IL7 production and lymphopoiesis while promoting leukemia growth.

Tumoroscope maps cancer clones in tumor tissues by integrating spatial transcriptomics, whole exome sequencing, and pathological images to reveal spatial patterns and clone-specific gene expression.

This study identifies QKY's role in stabilizing SUB at the plasma membrane by promoting SUB homo-oligomerization and forming a QKY-SUB complex.

This study shows CD73-generated adenosine reduces neutrophil-driven tissue damage and metaplasia in pancreatitis by promoting inflammation resolution.

The paper shows that convergent evolution of Omicron variants evades antibodies from BA.5 infections while maintaining ACE2 binding, driven by immune imprinting.

The paper develops a theoretical framework and validates it experimentally to show that even allocation of benefits stabilizes microbial communities engaged in metabolic division of labor.

This study identifies PDK4-dependent hypercatabolism in senescent cells that creates an acidic microenvironment, promoting cancer resistance and age-related pathologies.

This study shows that DeltaNp63 is essential for maintaining epidermal homeostasis, stemness, and inflammation suppression in adult skin, with its loss causing psoriasis-like inflammation and impaired wound healing.

SIC50 uses a vision transformer and Sobel operator to determine IC50 from phase-contrast images, validated with four drugs and 1536-well plates.

A single dose of therapeutic interfering particles reduces SARS-CoV-2 shedding and transmission in hamsters.

This study shows that the p73{gamma}-Leptin pathway promotes tumorigenesis and alters lipid metabolism by demonstrating that E11 deletion increases p73{gamma} and Leptin, leading to oncogenic effects in mice and human cancers.

This study maps spatial immune cell composition in human TB lung tissue, revealing diverse non-necrotizing aggregates surrounding necrotizing granulomas.

The paper identifies ID1 as an autonomous phosphate regulator that modulates the miR399-ZmPHO2 signaling module to maintain Pi homeostasis in maize.

The paper identifies a fungal effector that enhances RPW8.2 nuclear localization and transcription, boosting immunity in Arabidopsis against powdery mildew.

This paper engineers MAIT cells with CARs to target cancer cells, showing comparable cytotoxicity to CD8+ CAR-T cells but with lower IFN-γ expression.

This study shows honeybees use the waggle dance to obtain both a flying direction and a map-like coordinate system to locate food sources.

This study identifies mce3R mutations causing contezolid resistance in Mycobacterium tuberculosis by increasing Rv1936-mediated drug degradation.

This study investigates how Oreorchis patens responds to cold stress by analyzing physiological, biochemical, and molecular mechanisms, identifying differentially expressed genes and confirming their roles through qRT-PCR.

The paper introduces PRM-SRS imaging to visualize and identify multiple lipid species in cells and tissues with high chemical specificity and subcellular resolution.

The paper identifies potassium homeostasis as essential for medulloblastoma maintenance using a novel transposon system in mice and human samples.

This study examines age-related changes in vitellogenin vesicles and yolk organelles in C. elegans, finding significant expansion and fusion of these structures in post-reproductive worms.

This study develops a microneedle patch that delivers mesenchymal stem cell-derived exosomes to treat spinal cord injury, showing improved tissue recovery and functional outcomes in rats.

This study shows that asparagine restriction induces a biphasic response in CD8 T cells, enhancing their metabolic fitness and antitumoral function through ATF4/NRF2-dependent mechanisms.

This study shows that osteocyte ablation in mice leads to senescence-associated changes in bone and bone marrow lineages, causing sarcopenia, osteoporosis, and shortened lifespan.

The paper identifies the re-emergence of SADS-CoV in pigs in Guangxi, China, through qPCR and metagenomic analysis, suggesting undetected circulation since 2019.

This study shows that kynurenic acid reduces A1 astrocyte activation and promotes A2 astrocyte formation, improving cognitive deficits in HIV-1 gp120 transgenic mice.