X. Fan

The paper introduces a database that compiles antibody responses and clinical data from COVID-19 patients for analysis and visualization.

This study identifies SIRT1's role in regulating sphingolipid metabolism and neural differentiation in mESCs via c-Myc and SMPDL3B, suggesting therapeutic potential for neurological diseases.

This paper develops hybrid nanovesicles combining tumor exosomes and AIE nanoparticles for enhanced NIR-II imaging and photothermal therapy of tumors.

The paper defines and extends the near-infrared biological window for improved in vivo fluorescence imaging, proposing new regions and demonstrating enhanced imaging capabilities.

This paper develops a mucosal RSV vaccine, P-KFD1, which protects mice against RSV infection without vaccine-enhanced disease and relies on CD4+ T cell responses mediated by IFN-γ or IL-17A.

This study evaluates SARS-CoV-2 susceptibility in cell lines used for influenza and other virus diagnosis, finding that some are permissive while others are not, with MDCK cells being insusceptible due to low ACE2 expression.

This study shows that SR-A1 facilitates Leptospira phagocytosis by macrophages but also promotes bacterial dissemination and inflammation, worsening leptospirosis in mice.

This study shows metformin reduces high glucose-induced endothelial ROS through the AMPKα-Lin-28-OGG1 pathway in HUVECs and diabetic mice.

This paper introduces GETMap, a method to determine tissue origin of plasma DNA carrying genetic variants, validated across prenatal testing, transplantation, and oncology scenarios.

This study shows the SARS-CoV-2 D614G variant has enhanced replication and transmissibility in animal models, explaining its global dominance.

This study shows that SARS-CoV-2 structural stability decreases with temperature, supporting the seasonal pattern of viral infectivity.

This study finds that cutting sugarcane at 5 cm depth increases root fresh weight, volume, and fine root development, leading to higher cane yield compared to 0 or 10 cm cutting depths.

This study shows that repopulating Kupffer cells in adult mice originate directly from hematopoietic stem cells, not from preexisting Kupffer cells or monocytes.

This study analyzes immune responses in COVID-19 patients using single-cell RNA sequencing to identify differences in immune cell behavior across disease severity stages.

The paper identifies monocyte subsets with high osteoclastogenic potential and shows IRF8 regulates their epigenetic and transcriptional programs.

This study demonstrates that indocyanine green (ICG) emits strong NIR-IIb fluorescence when dissolved in protein solutions, enabling high-resolution bioimaging with improved signal-to-background ratio.

This study examines how environmental factors and landscape heterogeneity influence genetic structure in wild rice Zizania latifolia across a latitudinal gradient in China.

This study designs excretable AIE dots for deep-tissue imaging in marmosets, demonstrating their biocompatibility and excretion capabilities.

This paper presents a microfluidic ELISA technology for rapid, quantitative, and sensitive detection of SARS-CoV-2 biomarkers in small sample volumes.

This paper presents full-length transcriptome data of Ascosphaera apis mycelium and spore using PacBio SMRT sequencing, providing high-quality transcripts for genome and transcriptome annotation improvements.

Click-ExM expands super-resolution imaging to all biomolecules by integrating click-labeling into expansion microscopy.

This paper develops an AI tool for colorectal cancer diagnosis using histopathology images, achieving high accuracy and consistency across multiple centers.

This study examines how social support moderates the relationship between role conflicts and job satisfaction among nurses with multiple roles in China.

This paper introduces a method for preparing high-yield monolayer graphene cryo-EM grids that improve resolution and protein density for cryo-EM studies.

This study uses single particle cryo-EM to determine the structure of 52 kDa streptavidin at 3.2 Angstrom resolution, demonstrating the feasibility of high-resolution imaging for small molecules.

The paper shows nuclear actin enhances RNA polymerase II clustering during inducible transcription, facilitating rapid gene expression in response to stimuli like serum and interferon-gamma.

This paper develops a laser-based system to record subcellular neuron activities with high sensitivity, showing that ultrasound can modulate neuron laser emissions.