X. Gou

De novo design of drug-binding proteins with predictable binding energy and specificity

This paper designs drug-binding proteins with low nanomolar affinity and predictable specificity using computational methods, validated by experimental measurements and structural analysis.

An oligosaccharide analog exhibited antifungal activity by misleading cell wall organization via targeting PHR transglucosidases

This paper shows that a chitosan oligosaccharide analog disrupts fungal cell wall organization by targeting PHR transglucosidases, leading to antifungal activity and synergy with existing fungicides.

Effects of homoeologous exchange on gene expression and alternative splicing in a newly formed allotetraploid wheat

This study investigates how homoeologous exchange affects gene expression and alternative splicing in synthetic allotetraploid wheat, finding cis- and trans-regulatory impacts on gene expression and AS events.

Clinically applicable histopathological diagnosis system for gastric cancer detection using deep learning

This paper develops a deep learning system for gastric cancer detection using histopathological images, achieving high sensitivity and robust performance across different scanners.

Convergent genomic signatures of high altitude adaptation among domestic mammals

This study identifies convergent genomic signatures of high altitude adaptation in domestic mammals by analyzing 327 genomes, revealing positive selection in genes like EPAS1 and C10orf67.

Natural selection on TMPRSS6 associated with the blunted erythropoiesis and improved blood viscosity in Tibetan Pigs

This study identifies a deletion in TMPRSS6 associated with reduced hemoglobin and improved blood viscosity in Tibetan pigs adapted to high altitude.

Species composition and environmental adaptation of indigenous Chinese cattle

The paper analyzes genetic diversity and adaptation in indigenous Chinese cattle, identifying genes associated with environmental adaptation and confirming historical admixture patterns.