X. Wu

This paper presents a method using unnatural amino acid-engineered drug-resistant influenza virus to sterilize drug-resistant strains, validated in vitro and in animal models.

This study identifies ORF8 as a secreted glycoprotein that drives severe COVID-19 through NLRP3 inflammasome activation and shows it is inhibited by MCC950.

This study shows MAL suppresses OSCC by maintaining epithelial differentiation, with MAL and its co-functional genes as potential biomarkers for prevention and therapy.

The paper uses Cell Painting to predict the functional impact of lung cancer variants by analyzing cell morphology at the single-cell level.

This study investigates how grafting affects anthocyanin synthesis in grapevines by analyzing metabolomic and transcriptomic profiles across different grafting conditions.

This study shows TRIM47 enhances endothelial activation and pulmonary inflammation by promoting K63-linked ubiquitination of TRAF2, leading to NF-κB and MAPK pathway activation.

This study identifies pD345L as an ASFV protein that inhibits NF-κB signaling by blocking IKK kinase activity, providing insights into ASFV immune evasion mechanisms.

This paper demonstrates that intranasal nanobody Nb22 provides short-term instantaneous prophylaxis and effective treatment against SARS-CoV-2 in hACE2 mice, with ultrahigh potency and long-lasting retention in the respiratory system.

This study shows that dietary methionine restriction worsens cancer growth and reduces anti-tumor immunity via gut microbiota and immune suppression in immunocompetent mice.

This study uses BioID and BioSITe to map TNK2's interactome, identifying known and novel binding partners and validating one with immunoblot.

The paper shows that an actomyosin arc network formed by LFA-1:ICAM-1 interactions is essential for integrin-dependent immune synapse formation in B cells.

This paper introduces a method using nanobody-binding scaffolds to determine the structure of small proteins via cryo-EM, demonstrating its effectiveness with the KDEL receptor and SARS-CoV-2 RBD.

This paper presents a drug candidate, NANA-Me, that prevents and treats ADAA-based diseases caused by pathogenic anti-spike antibodies in COVID-19 and vaccines.

The study tracks IgG antibody levels against SARS-CoV-2 RBD in convalescent plasma donors over 12 months, showing sustained positivity and gender/age-related differences.

This study shows that microglia and border-associated macrophages in Alzheimer's disease are not replenished by bone marrow-derived cells, maintaining their embryonic origin.

The paper identifies 41 viral clusters in groundwater plasmidomes, links them to bacterial hosts, and detects novel phage genera and host-specific genes.

This study identifies Tcfl5 as a testis-specific protein essential for male fertility, showing that heterozygous mice are infertile and exhibit abnormalities in spermatids and spermatozoa.

The paper uses live imaging to show that timing of meristem transitions in fern gametophytes affects their morphology.

This study profiles the tumor immune microenvironment of NSCLC using multiplex immunofluorescence, identifying three immune subtypes and an immune-related risk score for prognosis prediction.

This study visualizes the structural progression of the cytokinetic contractile ring in sea urchin embryos, showing myosin II clusters with anillin and septin, and the formation of a septin filament network.

This study constructs high-resolution spatial transcriptomes of primary liver cancers to analyze spatial architecture and identify tumor microenvironment features.

This paper introduces a multiview super-resolution microscopy approach that enhances confocal microscopy resolution and reduces phototoxicity across multiple scales.

This study identifies two non-coding A-to-T mutations at the Kozak site of the N gene as potentially contributing to the transmissibility of Alpha, Delta, and Omicron SARS-CoV-2 variants.

This study shows that high oxygen tension upregulates integrin α6 in nucleus pulposus cells, which protects against intervertebral disc degeneration by reducing apoptosis and oxidative stress.

This paper develops a p-ELISA method using a multiepitope fusion protein to diagnose bovine and goat brucellosis, achieving high sensitivity and specificity.

This study uses time-sequential miRNA expression data from a mouse AML model to identify state transitions during leukemogenesis and shows the model predicts time to AML development.

The paper uses single unit analysis and wide-field imaging to study excitatory and inhibitory neuron alterations in glioma, finding mTOR inhibition reverses these changes.