X. Wu

The paper uses CRISPR/Cas9 to study alkaline phosphatase isoforms and their regulatory network in diatoms, revealing their functional differences and compensatory roles in phosphorus scavenging.

This study compares 16S rRNA and whole-metagenome sequencing in cervical cancer patients, finding congruence in diversity metrics but discrepancies in genus-level abundances.

This study develops and evaluates porous scaffolds combining HA, PLGA, and MSM for bone defect reconstruction, showing improved cell adhesion, proliferation, and drug release properties.

This study tracks gut microbiome diversity and composition changes in gynecologic cancer patients undergoing chemoradiotherapy, finding reduced diversity during treatment but partial recovery by week 12.

This study investigates how maternal hyperandrogenism and insulin resistance in pregnant rats affect ferroptosis in uterine and placental tissues, revealing differential molecular and cellular mechanisms.

This paper develops a SARS-CoV-2 proteome microarray to analyze antibody interactions at amino acid resolution and identifies epitopes and neutralizing antibodies in COVID-19 patients.

This study shows rottlerin reduces DSS-induced colitis in mice by enhancing intestinal barrier function through the Epac-2/Rap-1 signaling pathway.

This study reports cryo-EM structures of a P4-ATPase lipid flippase in lipid bilayers, revealing mechanisms of lipid transport and ATP coupling.

This study identifies IRF8 as a key factor in tumor-associated macrophages (TAMs) that induce T cell exhaustion by presenting cancer antigens, and shows its association with poor patient survival in renal cell carcinoma.

This study identifies multi-genetic mechanisms of metronidazole resistance in C. difficile, showing epistasis between iron homeostasis and oxidoreductases.

This study identifies a non-hypermucoviscous ST11 hypervirulent K. pneumoniae strain lacking classical virulence factors, showing increased virulence through ampR and WcaJ mechanisms.

The paper identifies 3,763 SUMO1 modification sites and their dependence on six SENP proteins, revealing SENP3's role in innate immunity through deSUMOylation of DHX15 and PCBP2.

This study identifies Myosin-7B and SLC35B2 as critical regulators of α-Synuclein fibril endocytosis, revealing a distinct pathway involving HSPG interactions and actin dynamics.

This study evaluates drug inhibitory effects on Babesia parasite growth using real-time PCR with 18S rRNA quantification and shows significant gene expression reduction after drug treatment.

This study shows P4HA2 is overexpressed in glioma and promotes cancer progression by enhancing proliferation, invasion, migration, and EMT, while also regulating the PI3K/AKT pathway through collagen expression.

This study demonstrates that cross-feeding between Thauera aminoaromatica and Rhodococcus pyridinivorans drives quinoline degradation in a denitrifying bioreactor through 2-hydroxyquinoline as an intermediate.

This study identifies ZNF704 as a driver of breast carcinogenesis by disrupting circadian rhythms through repression of PER2 and other clock genes.

This study identifies ZBED2 as a transcriptional repressor that antagonizes IRF1 to modulate cell identity and suppress interferon response in pancreatic cancer.

This study uses whole exome sequencing to track cervical cancer mutations during chemoradiation, finding that CDK4/CDK6/cyclin D1-related mutations persist or increase, suggesting radiation resistance.

This study identifies riboflavin as a direct mediator of electron transfer in microbial P450 monooxygenase dealkylation, revealing a novel mechanism involving FAD/FMN cofactors.

This study examines cannabinoid-related gene expression in disease cell lines, finding differences between normal and cancerous cells and across tissue origins, suggesting potential therapeutic applications for phytocannabinoids.

This study identifies Msi1+ cells as rapidly cycling intestinal stem cells that regenerate the intestine independently of Lgr5high cells.

This paper describes an RNA-based system to study HBV replication and predict drug resistance mutations.

This study identifies a non-genetic mechanism for cisplatin resistance in lung adenocarcinoma involving the integrin β4/paxillin axis and its regulation of USP1 and VDAC1.

The paper compares ChIP-seq profiles of ORC and MCM proteins with replication timing to show that active transcription affects ORC/MCM distribution and replication timing correlates with ORC density in human cells.

This study shows that PUFA analogues differentially modulate cardiac ion channels through distinct mechanisms, suggesting potential tailored therapies for specific LQTS mutations.

The paper identifies four humoral immune factors in Biomphalaria glabrata that coordinate to mediate resistance to Schistosoma mansoni infection.

The paper shows MSI-1 and EXC-7 regulate serotonin-mediated mating behaviors in C. elegans by stabilizing mRNA of a G protein and affecting serotonin synthase activity.

This study identifies SidJ as a bacterial pseudokinase that catalyzes polyglutamylation of SdeA, a Legionella effector, in a CaM-dependent manner, suppressing ADP-ribosylation.