Y. Guo

The paper investigates the dynamics and function of Munc18-mediated SNARE template complexes using optical tweezers, revealing a dynamic conformational transition that facilitates specific SNAP-25 binding.

This study evaluates the neutralization resistance of SARS-CoV-2 Omicron subvariants BA.4.6, BA.4.7, and BA.5.9 to antibodies, finding increased resistance to certain monoclonal antibodies and vaccine-induced sera.

This paper identifies a phosphorylation-based toxin/antitoxin system in Pseudomonas aeruginosa that regulates prophage activation and defends against lytic phages.

This study identifies SlMAP70 as a regulator of tomato fruit shape by interacting with SlIQD21 and modulating microtubule organization during fruit development.

This study identifies multiple mutational pathways leading to nirmatrelvir resistance in SARS-CoV-2 through in vitro experiments and structural analysis.

This paper identifies ALT in pediatric high-grade gliomas without ATRX mutations and links it to germline MMR variants.

This study characterizes the antigenic properties of the SARS-CoV-2 Omicron subvariant BA.2.75, showing increased neutralization resistance to vaccinated sera and specific monoclonal antibodies.

This paper introduces a complex-valued particle stack for cryoEM single particle reconstruction to improve data processing efficiency and resolution.

The paper identifies the re-emergence of SADS-CoV in pigs in Guangxi, China, through qPCR and metagenomic analysis, suggesting undetected circulation since 2019.

This study uses single-cell sequencing to analyze immune cell dynamics across human lifespan, identifying age-related changes in T cell function, cell interactions, and B cell subsets.

The paper determines the force-distortion relationship of Piezo channels using vesicle shape measurements and derives their intrinsic curvature and bending stiffness.

The paper predicts and measures the membrane footprint of Piezo proteins using elasticity theory and cryo-electron tomography, showing agreement across vesicle sizes and revealing a spherical cap geometry.

This study investigates rhubarb's effects on constipation-induced inflammation, gut microbiome, and metabolism in mice, showing improvements in cytokine balance, microbial diversity, and fatty acid metabolism.

SunRISE enables long-term live-cell imaging of individual mRNAs by combining SunTag technology with epifluorescence microscopy to study mRNA dynamics.

This study analyzes antibody evasion by SARS-CoV-2 Omicron subvariants BA.2.12.1, BA.4, and BA.5, finding BA.4/5 shows greater resistance to neutralizing antibodies than BA.2.12.1.

MADET is a manually curated database that compiles 453 microbiota-drug associations from 24 papers to aid in understanding microbiota's role in anticancer drug efficacy and toxicity.

This study identifies introgressed haplotypes from wild sheep species associated with morphological traits in domestic sheep using whole-genome sequencing.

The paper investigates m6A-mediated regulation of flavor metabolites in tea leaves during solar-withering, identifying key m6A erasers and their impact on terpenoid and flavonoid biosynthesis.

This study shows that IDOL deficiency reduces atherosclerosis in rabbits fed a high-cholesterol diet by improving lipid metabolism and bile acid excretion.

This paper identifies LecB as a Pseudomonas aeruginosa lectin that triggers PI3K signaling and caveolin-1 recruitment at the apical membrane to promote host cell invasion.

This paper develops compact human mechanosensitive TADs for synthetic transcriptional control, showing they are potent, versatile, and well-tolerated in primary cells.

The paper shows that differences in peptide binding between chicken MHC class I alleles BF2*1901 and BF2*1501 explain their differing susceptibility to Mareks disease.

This paper demonstrates using smartphone-based sensors to measure plant wettability for environmental monitoring and pollution assessment.

This study shows PKD-1 signaling is essential for maintaining CSCs with epithelial-mesenchymal plasticity in pNETs, suggesting it as a therapeutic target.

This study characterizes the antigenic properties of SARS-CoV-2 Omicron sublineages BA.1+R346K and BA.2, showing they exhibit significant antibody evasion similar to BA.1.

LIFE-Seq is a method for analyzing transgene integration in GMOs using DNA probes and PacBio sequencing, offering improved accuracy and cost-effectiveness compared to whole-genome sequencing.

This study shows that RfxCas13d causes mouse death by collateral cleavage of 28s rRNA, highlighting biosafety concerns for CRISPR-Cas13 systems.

The paper screens FDA-approved drugs to find inhibitors of NDM-1, restoring carbapenem efficacy against resistant bacteria.

The paper analyzes co-mutations across multiple cancer types to identify cooperating mechanisms in tumorigenesis and their clinical implications.

This study identifies adaptation mechanisms of Klebsiella aerogenes in oral and gut mucosae, revealing distinct gene usage for colonization in each environment.