Y. Guo

This paper designs, synthesizes, and evaluates three novel NCMN polymers for membrane protein structural biology, finding that NCMNP21b-x produces high-quality particles suitable for cryo-EM.

A single intranasal dose of bacterial therapeutics modulates the bovine nasopharyngeal microbiota, reducing diversity and strengthening bacterial interactions without adverse effects.

This study compares the functional properties of the B.1.1.529 SARS-CoV-2 spike glycoprotein with previous variants, finding reduced processing and lower stability but equivalent infection efficiency and increased ACE2 binding affinity.

The paper reports a cryo-EM structure of the SARS-CoV-2 Omicron spike protein, revealing how mutations alter its conformation and enable antibody resistance.

This study shows that the Omicron variant of SARS-CoV-2 is highly resistant to neutralization by convalescent serum and vaccines, and many monoclonal antibodies.

The paper identifies a human monoclonal antibody that neutralizes all tested sarbecoviruses and describes a new antibody class with potential for pandemic preparedness.

This study shows dihydroartemisinin (DHA) enhances anti-PD-1 therapy in hepatocellular carcinoma by inhibiting YAP1 and disrupting immune evasion through PD-L1, JAK1/STAT1, and JAK3 pathways.

This study compares neuromuscular recruitment strategies in men and women during isometric contractions, finding women use smaller motor units with higher firing rates while both sexes show similar force production strategies.

The paper reviews marine microbiome studies, analyzes 17.59 Tb of sequencing data, and constructs genome and gene catalogues to explore marine prokaryotic diversity and function.

This study identifies dysregulated eIF4F translation initiation complex in HS lesions, linking it to SCC development through Cyclin D1 and c-Myc overexpression.

This paper identifies a monoclonal antibody, 2-36, that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses, with a conserved epitope in the RBD identified through cryo-EM.

This paper introduces a deep learning method for single-frame super-resolution microscopy, enabling live-cell imaging at nanometer-scale spatial and millisecond temporal resolutions.

This study shows SARS-CoV-2 indirectly causes BBB injury and neuroinflammation through systemic inflammation, not direct viral infection, using a linked alveolus-BBB organ chip platform.

This study identifies ten Shaker K+ channel genes in foxtail millet and analyzes their expression under abiotic stresses and ABA treatment, revealing distinct regulation patterns.

This paper identifies a monoclonal antibody, 2G1, that neutralizes all SARS-CoV-2 variants with high potency and describes its mechanism of action and therapeutic efficacy in animal models.

This paper develops Ub variant inhibitors for JAMM-family DUBs STAMBP and STAMBPL1, showing high affinity and selectivity, with structural insights and improved potency over existing inhibitors.

The paper screens a fragment-based library to identify inhibitors of Lassa virus endonuclease, finding two benzotriazole compounds that inhibit viral minigenome activity and show synergistic antiviral effects.

This paper reports the cryo-EM structure of antibody 5-7, which binds to a distinct site in the SARS-CoV-2 spike NTD, showing neutralization resistance to variants of concern.

This study shows that combined thermal and mechanical stimuli synergistically enhance chondrogenesis through calcium signaling via TRPV4 channels.

This study identifies pS273R as an ASFV protease that inhibits the cGAS-STING pathway by targeting IKKε, revealing a new immune evasion mechanism.

This study investigates how L-alanine, an amino acid-derived quorum sensing molecule, enhances the gastrointestinal tolerance of Lactobacillus acidophilus in a co-culture fermentation model.

This study identifies ZmHXK7 as a maize hexokinase gene that improves salt tolerance in transgenic Arabidopsis by enhancing seedling growth and reducing stress inhibition.

The paper reprograms human B cells to express HCDR3 regions of HIV-1 bNAbs, enabling diverse and physiologic repertoires that efficiently bind HIV-1 antigens.

This study shows that ribosomal protein (RP) deficiency affects gene expression through translational and transcriptional changes, with distinct impacts on cell growth, apoptosis, and development.

This study identifies σ3 as a reovirus virulence factor that suppresses PKR activation and stress granule formation, linking these functions to viral replication and myocardial injury in mice.

This paper identifies a conserved BAH module in BAHD1 that reads H3K27me3 and mediates gene silencing by recruiting histone deacetylases, essential for development.

This study identifies HSP90 inhibitors as potential drugs for TSC1/TSC2 deficient cancer but finds rapamycin is more effective in vivo despite modest in vitro inhibition.

This study reports cryo-EM structures of two SARS-CoV-2 neutralizing antibodies bound to spike proteins of emerging variants, showing they retain potency despite RBD mutations.

The paper compares transcriptomic profiles of different human trophoblast development models to identify differentially expressed genes and transcription factors.

The paper identifies a conserved mechanism involving ferritin proteins that enhances cold survival in nematodes and mammalian neurons by detoxifying iron-related reactive oxygen species.