Y. Guo

This study evaluates the neutralization resistance of SARS-CoV-2 variants B.1.1.7 and B.1.351 to monoclonal antibodies and sera, finding increased resistance in B.1.351.

The paper determines structures of three VH1-2-derived antibodies in complex with SARS-CoV-2 spike, revealing modular recognition mechanisms and conformational changes.

This study identifies potent SARS-CoV-2 neutralizing antibodies targeting the N-terminal domain (NTD) and reveals they bind a common supersite on the spike protein.

This study examines co-infection and secondary infection rates in COVID-19 patients, finding low rates of Streptococcus pneumoniae co-infections and common secondary pathogens like S. maltophilia.

The study identifies a 416-bp deletion in the AFF gene's promoter that reduces its expression, leading to all-flesh tomato fruits and providing insights into berry fruit evolution.

This study shows that RUNX1 addiction is a therapeutic target in acute lymphoblastic leukemia, as inhibiting RUNX1 activity spares normal hematopoiesis and affects multiple genetic subtypes.

This paper develops a microengineered lung organ chip model to study SARS-CoV-2-induced lung injury and immune responses, revealing distinct cellular responses and the role of immune cells in inflammation.

This study identifies TRPM4 as a key regulator of pressure overload-induced cardiac hypertrophy by modulating CaMKII{delta}-HDAC4-MEF2A and calcineurin-NFAT-GATA4 pathways in mice.

This study shows that Atg5 in intestinal myeloid cells limits IL-12 secretion, preventing dysbiosis and inflammation by reducing IFN-gamma production.

The paper shows that N-linked glycosylation in Piezo1 channels is essential for plasma membrane trafficking and that mutations affecting this process are linked to disease.

This study identifies RBM39's role in promoting PRRSV proliferation by altering c-Jun phosphorylation and binding viral RNA.

This paper introduces spatially expandable fiber-based probes for deep brain interface, enabling three-dimensional recording and stimulation of neural activity with high resolution and minimal tissue damage.

This study shows that reovirus σ3 protein reduces interferon production and necroptosis by mechanisms unrelated to its dsRNA binding ability.

This study identifies EGFR downregulation as a mechanism by which HPV infection improves prognosis in cervical and head and neck cancers, suggesting EGFR inhibitors could be potential anti-HPV therapies.

This study develops mouse monoclonal antibodies against SARS-CoV-2 spike protein that show neutralizing activity and are suitable for immunoassays and large-scale production.

The paper shows that His-tags affect particle orientation in cryoEM by modulating interactions with the water-air interface, suggesting their use for controlling preferred orientation patterns.

This paper develops an intestine-on-chip model to study SARS-CoV-2 infection, showing intestinal damage and immune response similar to human infection.

The paper tests whether beta-diversity contributes to the latitudinal gradient in species richness by analyzing tree species data across East Asia.

This study identifies the origin of photoperiod non-responsiveness in barley by analyzing genetic variation and haplotype relationships in wild and domesticated barleys.

The paper investigates cohesin's role in neuronal gene expression in CdLS by analyzing transcriptomes and showing partial rescue of gene deregulation through cohesin reconstitution.

This paper identifies a potent neutralizing antibody targeting the N-terminal domain of SARS-CoV-2 Spike protein, revealing it as a new therapeutic target.

The paper shows that pDCs enhance innate immune defense against Aspergillus by amplifying neutrophil activity through CXCR3-dependent crosstalk during infection.

This study shows that rats with dorsomedial striatal lesions exhibit persistent cognitive flexibility deficits during reversal learning in a 3-CSRT task, despite normal accuracy acquisition.

This study investigates the genetic and environmental factors influencing growth rate variation in Arabidopsis thaliana, finding polygenic adaptation and environmental plasticity as key drivers.

This paper introduces a method for delivering cells to infarcted mouse hearts using echocardiography-guided percutaneous injection, showing improved cardiac function with repeated dosing.

The paper compares silicone and cotton swabs for RNA extraction in COVID-19 testing, finding silicone swabs yield higher RNA concentration and quality.

This study characterizes the negative effects of corn stover hydrolysate on industrial S. cerevisiae and identifies transcriptomic responses during the lag phase.