Y. Guo

This study develops an estrogen-inducible CRISPR/Cas9 system in Nicotiana tabacum and demonstrates its efficacy in inducing targeted mutagenesis of the NtPDS gene.

This study determines the cryo-EM structure of human ACE2 bound to the RBD of 2019-nCoV, revealing key interactions and differences compared to SARS-CoV.

This study isolates and characterizes a coronavirus from Malayan pangolins that is highly similar to 2019-nCoV, suggesting pangolins may act as an intermediate host.

The paper develops an in vitro vesicle formation assay to identify proteins involved in cargo sorting and trafficking, revealing novel regulators like FAM84B and PRRC1.

This study develops a computer vision method to analyze C. elegans swimming behavior and identifies genetic factors influencing exercise-induced quiescence.

This study shows that acetyl-CoA from specific metabolic pathways enhances cardiac repair after myocardial infarction by promoting histone acetylation and antioxidant gene expression.

This paper identifies functional noncoding SNPs and their molecular mechanisms for 19 autoimmune diseases using multi-omics data and prioritizes drug targets.

dNEMO quantifies mRNA and punctate structures in single-cell time-lapse images using wavelet transforms and manual curation for accurate measurements.

This paper reveals the atomistic mechanism of NompC channel opening under intracellular compression using simulations and experiments, showing force transmission through ankyrin repeats and linker helices to the TRP domain.

This study shows that K14-dependent disulfides regulate epidermal homeostasis and barrier function through interactions with 14-3-3sigma and YAP1.

This study analyzes how uncorrected optical aberrations affect cryo-EM single particle reconstruction and provides a method to assess information loss.

The study identifies widespread distribution of beta satellite DNA across eukaryotes, suggesting multiple horizontal transfers and origins in primate ancestors.

The paper identifies proteins bound to metaphase ESC chromosomes and shows chromatin repressors are involved in maintaining chromosome compaction.

This study develops a rapid and efficient cowpea transformation system using embryonic axis explants, achieving transgenic shoot frequencies of 4.5 to 37%.

The paper assesses CRC screening and follow-up colonoscopy rates in a Chinese urban district, finding low participation and follow-up rates despite high CRC prevalence.

The paper analyzes the kinetic stability of the LMO2/LDB1 complex subunits and identifies LDB1 as a stabilizer and nucleator of the complex.

This study identifies a comprehensive atlas of B-lymphocytes in triple-negative breast cancer using single-cell RNA-sequencing and antigen receptor profiling, revealing their mature characteristics and prognostic significance.

This study shows that loss of cyclin A2 in colonic epithelial cells causes DNA damage, dysplasia, and colon inflammation, while high cyclin A2 expression is linked to better prognosis in colorectal cancer.

The paper investigates how soil properties affect kiwifruit quality in Northwest China, finding specific soil factors influence different fruit quality traits.

This paper evaluates the combination of artesunate and tetramethylpyrazine for treating experimental cerebral malaria, finding improved survival and neurological protection through proteomic analysis.

The paper identifies beta satellite DNA sequences in non-primate species, suggesting horizontal gene transfer from hominid hosts.

This study identifies gut bacteria, particularly Clostridiales, as a source of tacrolimus metabolism, producing less potent metabolites that may explain variable drug exposure after oral dosing.

The study examines EGFR exon19 mutation subtypes in non-small cell lung adenocarcinoma and finds that CSS mutations are associated with shorter progression-free survival compared to CD/CSS+SNV mutations.

This paper develops a method to consistently measure Fj and Fi in PSII chlorophyll fluorescence induction by tracking curvature, improving accuracy under varying conditions.

This study investigates the effect of L. reuteri on immune parameters and gut microbiota, revealing sex-specific differences in immune response and microbial composition.

The paper assesses H. pylori stool shedding and cagA genotype in gastric cancer patients and non-cancer controls, finding higher stool shedding and association with the East Asian cagA allele.

This study identifies natural variation in OsLG3 that enhances drought stress tolerance in rice by improving ROS scavenging, offering a genetic resource for breeding drought-tolerant rice.

This study identifies AST1, a Trihelix transcription factor in Arabidopsis, which enhances abiotic stress tolerance by binding to AGAG-box and GT motifs, regulating stress-related genes and physiological traits.

This paper analyzes DNA nucleotide compositions across 371 genomes from different kingdoms and discusses GC content, codon usage, and thermophilicity.