Y. He

The paper shows that inhibiting glycogen phosphorylase with CP91149 synergizes with taxol to induce ferroptotic cell death in clear cell ovarian and kidney cancers.

This study shows that ATRX loss primes glioma cells for innate immune recognition, while IDH1R132H mutation suppresses immune signaling, which can be reversed by IDH1 inhibition.

The paper inserts large protein domains into AAV capsid protein VP1 to identify engineerable hotspots and assess capsid robustness to structural modifications.

This study uses a deep learning algorithm to discover highly divergent RNA viruses in metatranscriptomes, identifying 161,979 potential species and 180 supergroups.

This paper discovers and engineers an L-threonine aldolase from Neptunomonas marine to efficiently synthesize β-hydroxy-α-amino acids with high diastereoselectivity.

This paper develops FRESH 3D bioprinted cardiac tissues to improve in vitro pharmacology and toxicology screening by mimicking native-like physiological responses to adrenergic agonists.

This study identifies a C-terminal residue critical for SARS-CoV-2 spike protein trafficking and virion assembly, offering insights for vaccine design.

The paper develops a wide-band photoacoustic microscopy system to image cellular components in mouse brain tissue without labeling, revealing phospholipid distribution at 1690 nm.

The paper develops a high-throughput platform for screening functional neo-antigens and their specific TCRs using droplet microfluidics and DNA barcoding.

This study identifies PCNA's role in temperature stress tolerance of Ulva prolifera, showing its interaction with CyclinA and regulation by miR-2916 through the MAPK pathway.

This study shows that VEGFR2 in lymphatic endothelial cells promotes tumor metastasis by regulating lymphatic valve formation and tumor-associated lymphangiogenesis.

This study uses intravital microscopy to examine satellite cell dynamics and interactions with myeloid cells during skeletal muscle regeneration, revealing that direct contact is not required for early activation but is important for proliferation and differentiation.

The paper presents the Cryo-EM structure of DNA polymerase θ helicase domain with and without inhibitor novobiocin, revealing a non-canonical binding pocket and insights into its mechanism.

The paper develops a label-free optical imaging method for the lymphatic system using deep learning and applies it to clinical and animal studies.

This study identifies RELMα's role in sex-specific obesity protection by regulating adipose macrophages and eosinophils, revealing a therapeutic target for obesity.

This study measures stable isotope fractionation in Bombyx mori strains across life stages to trace isotope movement and understand fractionation patterns.

This paper develops an AI-assisted stimulated Raman cytology method to detect peritoneal metastasis in gastric cancer with high accuracy and speed.

This study identifies VHL mutation as a driver of CE accumulation in ccRCC through the PI3K/AKT pathway, showing that inhibiting cholesterol esterification suppresses tumor aggressiveness.

The paper identifies chloride as an allosteric activator and inhibitor of Class-D beta-lactamases, revealing its dual role in enzyme kinetics and suggesting new antibiotic strategies.

The paper characterizes a novel botybirnavirus, DtBRV1, found in Didymella theifolia, which infects tea plants, and identifies a unique dsRNA unit with distinct molecular features.

The paper generates and indexes an EMS mutant library for KN9204 wheat to enhance functional genomics and genetic manipulation for agronomic traits.

This study uses a computational model to show that ventricular systolic function affects thrombus formation after EVAR, with specific correlations identified.

This study investigates how flow-induced mechanical forces regulate YAP nucleocytoplasmic transport through actin cap formation and nuclear stiffness changes, revealing a unified mechanism linking mechanical stimulation to transcriptional regulation.

This study shows clemastine, an antihistamine, reduces glioblastoma stemness by targeting EBP, a cholesterol pathway enzyme, and promotes differentiation of oligodendrocyte progenitor cells.

This study identifies a novel catecholaminergic cardiomyocyte population expressing Dbh that contributes to the murine cardiac conduction system through transcriptomic, genetic, and optogenetic analyses.

The paper designs and characterizes a protein fold switching network where single amino acid substitutions can switch fold and function in proteins.

This study shows that extracellular matrix stiffness influences fibroblast differentiation by modulating DNMT1 expression via microtubule polymerization.

This study shows that Gaq-PKD/PKCμ regulates IκB transcription to limit NF-κB-mediated inflammation, essential for successful early pregnancy.

This paper introduces FD-DeepLoc, a deep learning method for high-throughput 3D super-resolution imaging over a large field of view using a sCMOS camera.

The paper identifies and characterizes a novel hypovirus and its satellite-like dsRNA from Pestalotiopsis fici, showing it lacks a poly(A) tail and ORF, and negatively regulates the helper virus.