Y. Huang

The paper identifies cis-regulatory changes in a gene linked to adaptive radiation in cichlid fishes by showing their impact on gene expression patterns across lineages.

This study identifies the GEMC1-MCIDAS transcriptional program as essential for multiciliogenesis in the choroid plexus and its role in preventing tumorigenesis.

The paper identifies STAT3 as an inhibitor of Myocardin-mediated cardiac hypertrophy by directly binding to Myocardin and suppressing its transcriptional activity.

The paper identifies a GATA2, TAL1, ERG regulatory circuit that promotes erythroid transition in both healthy and leukemic stem cells, showing its persistence in AML with minor alterations.

This study finds that patients with severe SARS-CoV-2 disease have higher antibody titers against viral proteins and neutralization capabilities compared to less severe cases.

This study shows that inactivating ATPIF1 enhances CD8+ T cell antitumor activity by reprogramming their metabolism, leading to better tumor suppression in mouse models.

This study finds urban land cover negatively affects flying insect biomass, while farmland has a positive effect, with varying impacts across spatial scales in Denmark and Germany.

The paper identifies ubiquitylated proteins in Arabidopsis during MAMP-triggered immunity, revealing the ubiquitin-proteasome system's role in immune regulation.

This study shows that myogenic vasoconstriction in mice depends on Gq/11 signaling through AT1aR, not β-arrestin-mediated pathways.

This paper introduces a cell-based assay to identify coronavirus 3CL protease inhibitors without live virus, demonstrating its effectiveness through compound screening and structure-activity profiling.

This paper develops a deep learning system for gastric cancer detection using histopathological images, achieving high sensitivity and robust performance across different scanners.

This paper develops membrane nanoparticles from ACE2-rich cells that effectively block SARS-CoV-2 infection by trapping the viral S1 protein and inhibiting its interaction with host cells.

This paper introduces a technique combining label-free histology with spatially resolved multi-omics to map gene expression and copy number alterations in human oral squamous cell carcinoma.

This study evaluates three fecal immunoassay technologies for detecting canine Echinococcus infection in China, finding that sensitivity is lower than expected and further development is needed.

This paper introduces a continuous constant pH molecular dynamics method to simulate proton-coupled conformational dynamics of transmembrane proteins.

The paper develops and simulates fully glycosylated ACE2-Fc fusion proteins and their interaction with SARS-CoV-2 spike protein RBD, showing glycan effects on conformation and optimizing glycosylation modeling algorithms.

The paper identifies three structurally diverse compounds as inhibitors of the SARS-CoV-2 3CL protease and provides structural insights for inhibitor design.

This study identifies two distinct CD4+ T cell subsets in the human liver, characterized by CD69 expression levels, with different functional profiles and microenvironmental requirements.

This study investigates how TSG promotes osteogenic differentiation of BMSCs by inhibiting KDM5A expression.

The paper isolates and characterizes 61 SARS-CoV-2-neutralizing monoclonal antibodies from infected patients, identifying potent antibodies targeting multiple epitopes on the spike protein.

This study develops a co-culture platform to study interactions between human colonic mucosal barriers and Faecalibacterium prausnitzii, showing anti-inflammatory effects and butyrate's role in modulating TLR3/4.

This paper creates a single-cell transcriptomic atlas of the Chinese horseshoe bat to study its role as a viral reservoir, identifying cell types and receptor expression patterns related to viral entry.

This study compares metagenomic sequencing and qPCR for detecting influenza D virus in bovine samples, finding varying agreement rates between methods.

This paper identifies sTRA as a glycan biomarker for chemotherapy-resistant pancreatic cancer, showing its presence correlates with poor treatment response in multiple systems.

The paper develops a method to construct habitat-specific training sets for species-level taxonomic assignment of 16S rRNA gene sequences, validated using human aerodigestive tract microbiota data.

This study identifies ARTS as a p53-responsive gene that promotes mitochondrial apoptosis by interacting with p53 and enhancing its pro-apoptotic effects.

This paper introduces a rapid, point-of-care red blood cell agglutination assay for detecting SARS-CoV-2 antibodies using a fusion protein that binds RBCs and displays the SARS-CoV-2 RBD.

This paper optimizes interferential stimulation (IFS) using electrode arrays to achieve focal brain stimulation, showing it can be more focal than conventional HD-TES but with lower intensity.

This study identifies TbUnc119 as a myristoylated cargo carrier in Trypanosoma brucei, showing its role in targeting the arginine kinase TbAK3 to the flagellum via the conserved LIFT pathway.

This study uses hPSC-derived lung organoids to identify FDA-approved drugs that inhibit SARS-CoV-2 entry and reduce infection in a model of human COVID-19.