Y. Huang

The paper uses molecular dynamics simulations to show that glycosylation enhances the binding strength and range of SARS-CoV-2 Spike to ACE2 through glycan-mediated interactions.

This study develops a recombinant SARS-CoV-2 spike protein vaccine, Covax-19, formulated with Advax-SM adjuvant, showing protection against COVID-19 in mice and ferrets.

This paper reports the cryo-EM structure of antibody 5-7, which binds to a distinct site in the SARS-CoV-2 spike NTD, showing neutralization resistance to variants of concern.

The paper infers and validates 5'UTR-leader sequences of immunoglobulin heavy chain variable gene alleles using transcriptome data and identifies novel upstream regions and variants.

This study uses deep metagenomics to explore microbial communities in Challenger Deep sediment, revealing new MAGs, metabolic functions, and virus-host interactions in hadal zone ecosystems.

This paper evaluates the impact of an information sharing system on supply chain performance for donated medicines against NTDs, finding improved timeliness in purchase, arrival, and delivery.

This study shows that deleting HIF2 in cancer-associated fibroblasts reduces pancreatic tumor growth and immunosuppression, suggesting HIF2 as a therapeutic target.

The paper examines gene regulatory evolution in cold-adapted Drosophila populations, finding parallel expression changes and varying cis-trans regulatory contributions across populations.

This study develops yolk sac-like organoids from hiPSCs to generate multipotent hematopoietic progenitor cells in a scalable and xeno-free system.

This study compares four single-particle analysis platforms for sizing, counting, and phenotyping extracellular vesicles and synthetic particles, identifying differences in performance across modalities.

This study identifies a young gene in Arabidopsis thaliana that shows strong positive selection and contributes to morphological trait divergence through neofunctionalization.

This paper develops a method to create 3D vascularized tissues using bioprinting and surgical anastomosis, showing improved viability and functionality in liver-like constructs.

This study investigates the effects of EPA and DHA on C2C12 cell differentiation, finding that DHA induces a white-like adipocyte phenotype while EPA does not.

This study evaluates glycoproteomics software performance using human serum datasets, identifies high-performance strategies, and provides recommendations for improved analysis.

This study shows the SARS-CoV-2 P.1 variant is more resistant to antibody neutralization than previous variants, but less affected by vaccine-induced immunity.

This study reports cryo-EM structures of two SARS-CoV-2 neutralizing antibodies bound to spike proteins of emerging variants, showing they retain potency despite RBD mutations.

The paper identifies a chemical inhibitor of the CorC Mg2+ transporter and provides structural insights into its mechanism of action.

This study evaluates the neutralization resistance of SARS-CoV-2 variants B.1.1.7 and B.1.351 to monoclonal antibodies and sera, finding increased resistance in B.1.351.

This study identifies 475 novel sRNAs in Salmonella enterica serovar Typhimurium that are differentially expressed during carbon starvation, confirming their role in stress response.

This study identifies potent SARS-CoV-2 neutralizing antibodies targeting the N-terminal domain (NTD) and reveals they bind a common supersite on the spike protein.

This study shows Ythdc1, an m6A reader, regulates LINE1 scaffold function in mouse ESCs, affecting self-renewal and differentiation through chromatin interactions.

This study shows that Artemisia annua extracts inhibit SARS-CoV-2 and its variants in vitro, with antiviral activity not linked to artemisinin or flavonoids, and suggests potential therapeutic use.

This study restores DNA repair genes in CHO cells, improving genome stability and protein titer.

This study shows that LEAFY, a floral regulator in Arabidopsis, binds both methylated and non-methylated DNA and can induce chromatin accessibility in target genes.

This paper develops a non-viral method for efficient T cell genome editing using modified plasmids, achieving CAR-T cell functionality comparable to AAV-based methods.

This study identifies a public antibody class, IGHV3-53/3-66, with potent SARS-CoV-2 neutralization capabilities through paired heavy and light chain interactions.

This study shows that neutralizing antibodies against SARS-CoV-2 need intact Fc functions and monocytes for optimal therapeutic protection in animal models.

The paper examines HDP gene expression and tissue distribution in different chicken breeds, finding correlations between body weight, age, and HDP expression in immune organs and intestine.

This study shows RAD51AP1 binds nucleosomes and aids RAD51 in chromatin-mediated DNA repair by facilitating donor DNA capture and joint-molecule formation.

This study identifies how EGFR differentiates signaling outputs from EGF and TGF- through conformational changes in its extracellular domain.