Y. Li

This paper shows that disrupting the Gβγ-SNAP25 interaction improves insulin action, promotes adipocyte browning, and protects against diet-induced obesity in mice.

This study shows heparin inhibits SARS-CoV-2 invasion by binding to the Spike protein's RBD and inducing conformational changes, with structural features of heparin playing a key role.

The paper analyzes SARS-CoV-2 sequence diversity and finds limited variation in the Spike protein, suggesting a single vaccine could be effective against current strains.

This study uses molecular dynamics simulations to show that Remdesivir's 1-cyano group inhibits SARS-CoV-2 RdRp by disrupting nucleotide addition and proofreading, providing insights for drug design.

The paper shows that monounsaturated fatty acids (MUFA) are essential for B cell function and humoral immunity, with SCD-mediated MUFA production supporting early B cell development and germinal center formation.

This paper introduces a computational light-sheet microscopy method that rapidly images entire organs at subcellular resolution, achieving high isotropic spatial resolution and significantly improved throughput.

A purified inactivated SARS-CoV-2 vaccine candidate (PiCoVacc) induces neutralizing antibodies in animals and shows safety and partial to complete protection against SARS-CoV-2 strains.

This study shows that prenatal arsenic exposure in mice leads to transgenerational impairments in spermatogenesis, associated with epigenetic changes in Igf2 and H19.

This study develops a human iPSC-CM model of DOX-induced cardiac dysfunction in B-cell lymphoma patients with high-dose DOX treatment, showing increased susceptibility to DOX toxicity and impaired mechanical function.

The paper shows that existing actin filaments guide new filament growth during cytokinesis, enabling alignment despite rapid filament turnover.

The paper investigates the host range of SARS-CoV-2 and related coronaviruses and identifies an improved ACE2-Fc variant effective against both SARS-CoV-2 and SARS-CoV-1.

The paper identifies bHLH11 as a negative regulator of Fe homeostasis in Arabidopsis, showing it inhibits bHLH IVc transcription factors by recruiting TOPLESS/TOPLESS-RELATED corepressors.

This study uses scRNA-seq to identify and characterize subtypes of human BM-MSCs in vivo, revealing their heterogeneity and potential differentiation trajectories.

This paper introduces a novel MRI/MRS method that selectively images specific metabolites by using nuclear spin singlet states, demonstrating molecular selectivity for endogenous molecules like N-acetylaspartate and dopamine.

This study shows that Borrelia afzelii does not suppress anti-tick immunity in bank voles, which negatively affects tick fitness and reduces pathogen transmission.

The paper compares silicone and cotton swabs for RNA extraction in COVID-19 testing, finding silicone swabs yield higher RNA concentration and quality.

This study designs, synthesizes, and evaluates two peptidomimetic aldehydes as antiviral drug candidates targeting SARS-CoV-2 main protease, showing potent inhibition and anti-infection activity.

This study identifies DDX5 as a regulator of tissue-specific oncogenic RNAs in intestinal tumorigenesis, showing its role in promoting colon and small intestine cancers.

This paper identifies elasnin as a potent antibiofilm agent that inhibits mono- and multi-species biofilms with low toxicity and resistance risk.

The paper identifies a novel chapparvovirus, fechavirus, associated with an outbreak of feline diarrhea and vomiting, alongside other viral pathogens.

The paper develops a method to improve 4Pi single-molecule localization microscopy by fitting an experimental PSF model, achieving the theoretical resolution limit.

This study investigates auxin regulation and MdPIN gene expression during adventitious root formation in apple cuttings, revealing their roles in cell division and organogenesis.

This study shows that LIF alone can reprogram 2i/LIF cultured ESCs to hypermethylated ESCs, demonstrating DNA methylation's essential role in LIF-dependent reprogramming and self-renewal.

This paper develops an AI tool for colorectal cancer diagnosis using histopathology images, achieving high accuracy and consistency across multiple centers.

This study shows that USP21 knockout in Treg cells disrupts immune regulation during Schistosoma japonicum infection, promoting parasite survival and altering immune responses while reducing immune pathology.

OsFIT interacts with OsIRO2 to enhance its nuclear accumulation and activate Fe-uptake gene expression in rice.

The paper isolates and characterizes SARS-CoV-2 from the first US COVID-19 patient, showing high replication in Vero cells and depositing the strain for public use.

This paper develops a transferable and interpretable deep learning model for MSI prediction from histopathology images, achieving high AUC scores in two cohorts.

The paper shows that SARS-CoV-2 Spike S1 RBD undergoes a conformational change when bound to heparin, suggesting potential for heparin as a therapeutic.