Y. Li

The paper investigates how carbon-based additives and ventilation rates affect nitrogen loss and microbial communities in chicken manure composting, finding that woody peat reduces nitrogen loss more effectively than other additives.

This study identifies the StarD domain of Them1 as a lipid sensor that allosterically regulates its activity and localization in response to fatty acids and lysophosphatidylcholine.

This paper shows that Them1 undergoes conformational changes in response to stimuli, forming biomolecular condensates that regulate fatty acid oxidation and thermogenesis.

The paper presents the cryo-EM structure of human ACE2 in complex with B0AT1, revealing dimeric conformations and potential binding sites for SARS-CoV spike proteins.

This study isolates and characterizes a coronavirus from Malayan pangolins that is highly similar to 2019-nCoV, suggesting pangolins may act as an intermediate host.

Endosidin20 inhibits cellulose synthesis by targeting the catalytic site of CESA6, reducing cellulose synthase complex delivery to the plasma membrane.

This paper introduces a de novo protein design algorithm called TopoBuilder that generates immunogens inducing precise antibody responses against respiratory syncytial virus in mice and non-human primates.

This paper identifies a dual activity in LanD-like flavoproteins for forming aminovinyl-cysteine residues through oxidative decarboxylation and cyclization of peptides.

This study reports cryo-EM structures of SIgA complexes, revealing their assembly mechanism and interaction with SpsA, a pneumococcal adhesin.

The paper quantifies vertebrate biodiversity in Ailaoshan reserve using leech iDNA, showing species richness increases with elevation and distance from the reserve edge.

This study examines the relationship between ocular biometrical parameters and diabetic retinopathy in Chinese adults with type 2 diabetes, finding associations between axial length, lens power, and AL/CR ratio with DR risk.

This study shows SHF-derived cells contribute to AngII-induced ascending aortic pathologies through LRP1 and TGF-β signaling, increasing PAI1 expression.

The paper identifies a mechanism by which RNA granules are transported via direct interaction with KIF5A/KLC1 motors, preventing axon degeneration in CMT models.

This study examines the effect of insulin therapy on OCT/A measurements in diabetic patients without retinopathy, finding thinner MCT and lower PVD in insulin users.

The study examines enzyme activities and microbial nutrient limitation across soil depths in subtropical forests, finding co-limitation by C and P rather than N.

This study identifies four clinically used drugs with high binding capacity to SARS-CoV main protease, a potential target for treating 2019-nCoV infection.

The paper identifies a CHD6 mutation causing Hallermann-Streiff syndrome and shows it disrupts autophagy and DNA damage response through chromatin remodeling.

The AIR Atlas provides a web-based resource for exploring inflammation and resolution processes, enabling bioinformatics analyses and systems biology approaches through integrated molecular interaction maps.

The paper shows that acetyl-CoA depletion disrupts nucleolar integrity, activates p53 via ribosomal proteins, and is mediated by class IIa HDACs regulating nucleolar phase state.

SMART-Q quantifies cell type-specific RNA transcripts by integrating smFISH data with cell identity information from immunostaining.

This study identifies LRRK2's role in lysosomal tubulation and vesicle sorting from damaged lysosomes, introducing the process LYTL.

This study shows that Bacillus subtilis spore enhances mucosal immunity by promoting intestinal-resident memory T cells through ICAM-1 expression on dendritic cells.

This study identifies differences in the oral microbiome between NPC patients and controls, highlighting a pair of co-excluding Granulicatella adiacens variants associated with cancer risk.

This study shows endogenous itaconate is not required for PM-induced NRF2 expression or inflammation, but exogenous itaconate can suppress inflammation and activate NRF2.

The paper introduces a HaloTag-TEV genetic cassette to study protein mechanics in native tissues, showing titin's role in muscle contraction under mechanical forces.

This study identifies DNA methylation of DZIP3 as a marker for early stage colorectal cancer, linked to aging and immune cell composition.

This paper sequenced two millipede genomes, revealing unique genomic features, defense systems, and microRNA regulation mechanisms in myriapods.

This study shows that RIP1 kinase activity in macrophages drives steatohepatitis by promoting cell death and inflammation, and its inhibition reduces liver injury in NASH models.

This study identifies stem cell-like GBM cells outside the contrast-enhancing region and proliferative lymphocytes in GBM patients' blood, linking them to recurrence and immunotherapy.

The study links indoor microbial communities in university dormitories to asthma symptoms, finding specific taxa from different ecological niches are associated with increased or protective effects on asthma.