Y. Li

This study shows that fecal microbiota transplantation (FMT) restores gut microbiota balance and protects the intestinal barrier in septic mice by enhancing short-chain fatty acid production.

This study shows that reducing keratin 1 in B16-F10 melanoma cells causes cell death and increased oxidative stress, suggesting K1 as a potential therapeutic target.

This study examines how the distribution of fitness effects and adaptive mutational spectra change after a single adaptive mutation in yeast, finding diminishing returns and historical contingency in subsequent adaptation.

This paper discovers a molecular glue, HQ461, that promotes CDK12-DDB1 interaction, leading to Cyclin K degradation and cell death.

ClipKIT trims multiple sequence alignments to retain phylogenetically-informative sites, improving phylogenomic inference accuracy and efficiency.

This study identifies active-site residues in TTLL enzymes that determine their specificity for initiating or elongating polyglutamate chains on tubulin, revealing structural basis for their functional specialization.

This study develops a network-based immunogenomics model to identify mutations affecting immune responses in cancer and suggests potential immunomodulatory drug candidates.

The paper tests insect frass as a feedstock for 3D-printing wood-based materials, finding drywood termite frass suitable for uniform layer deposition.

This study shows that S-enantiomers of chloroquine and hydroxychloroquine are more effective against SARS-CoV-2 and less toxic than their R-enantiomers, suggesting S-HCQ as a better treatment option for COVID-19.

This study identifies the tumor cell proteome of pancreatic cancer in vivo using BONCAT and DIA-MS, distinguishing it from non-tumor cells in the tumor microenvironment.

This study shows that the stringent stress response, mediated by ppGpp, regulates proteases and global regulators in Pseudomonas aeruginosa under optimal growth conditions, revealing its broad physiological role.

This study reconstructs the three-dimensional vasculature of Anaxagorea carpels, finding a radiosymmetrical pattern consistent with the Unifying Theory of carpel origin.

This study develops a thermostable anti-EBOV IgY antibody that retains neutralizing activity for one year at 25°C and provides complete protection in a mouse model.

This study identifies the RNA targets of Coronavirus EndoU, showing it cleaves viral RNA at UA and CA sequences to suppress antiviral responses.

This study compares the binding of SARS-CoV-2, SARS-CoV, and MERS-CoV spike proteins to glycans, finding HS binding is sulfation-dependent and sialic acid binding is absent.

The paper analyzes SARS-CoV-2 amino acid substitutions prevalent in the human population, finding they are mainly located in conserved segments of structural proteins and show varied success in the viral population.

This study develops a SARS-CoV-2 vaccine candidate using virus simulating particles that induces strong neutralizing immune responses with a single dose.

This paper establishes a theoretical variance lower bound for fluorescence microscopy image denoising using Cramer-Rao Lower Bound and microscope system properties.

This study compares the immune landscape of a genetically-engineered murine glioma model to human glioma using single-cell sequencing, finding similar immunosuppressive features but differences in immune cell composition between mouse models and human samples.

This study constructs a genome-scale phylogeny of Ascomycota fungi, revealing contrasting modes of genome evolution across subphyla.

This study compares the response of digesta- and mucosa-associated microbiota in Atlantic salmon to an insect meal diet, finding greater resilience in mucosa-associated microbiota.

This paper identifies a potent neutralizing antibody targeting the N-terminal domain of SARS-CoV-2 Spike protein, revealing it as a new therapeutic target.

This study identifies PDE6D as a potential target of sorafenib using PROTAC technology and proteomic analysis.

This study identifies a novel RNA-binding function for the circadian clock protein TOC1, revealing its role in regulating gene expression through RNA interactions.

A 573 bp insertion in the YFT1 gene's 5' UTR disrupts ethylene signaling and carotenoid synthesis, causing yellow fruit in tomato mutants.

This paper develops a novel mouse model for SARS-CoV-2 infection and evaluates the protective efficacy of an RBD-based subunit vaccine.

This study shows that protoporphyrin IX and verteporfin inhibit SARS-CoV-2 infection in vitro and in a human ACE2-expressing mouse model by blocking ACE2-S protein interaction.

This study shows that various glycosaminoglycans, beyond heparin, can induce conformational changes in the SARS-CoV-2 Spike S1 receptor binding domain.

This study shows low molecular weight heparins induce conformational changes in SARS-CoV-2 Spike RBD, suggesting potential for repurposing as antiviral agents.