Y. Li

This study identifies hypermutated IGHV3-53/3-66 antibodies from breakthrough infections that broadly neutralize SARS-CoV-2 variants including BQ and XBB.

This study evaluates the generalizability of a dengue classifier across multiple datasets, finding that logistic regression models perform well but require adjustments for new populations.

This paper introduces a method to precisely quantify molecular stoichiometry in vivo using single-molecule localization microscopy by analyzing fluorophore detections during the quasi-equilibrium state.

This study shows that combining proguanil and chlorhexidine with clarithromycin or rifampicin enhances antibacterial activity against Acinetobacter baumannii in vitro and improves treatment outcomes in mice.

This study develops a multivalent exosome-based vaccine platform that effectively induces strong immune responses against multiple viruses using minimal protein and no adjuvant.

This study identifies SMU_1361c as a transcriptional repressor regulating oxidative stress response in Streptococcus mutans, showing its role in pathogenesis and potential for therapeutic development.

This study identifies and characterizes the cryptic fungal pathogen Aspergillus latus, revealing its hybrid origin and developing genomic and phenotypic markers for accurate diagnosis.

This paper introduces a nanobead-based single-cell single-molecule pulldown (sc-SiMPull) method that is faster, easier, and more versatile than existing techniques for studying protein-protein interactions in single cells.

The paper characterizes BDW568, a non-nucleoside STING agonist, showing it activates STINGA230 variants in human cells and mimics endogenous ligands.

This paper develops a method to biodecompose Spirulina platensis using Bacillus subtilis to create a medium for high cell-density cultivation of Escherichia coli, achieving higher growth rates and optical density than traditional LB broth.

This study identifies novel rodent hosts of hepaciviruses, documents their diversity, and estimates the origin of the genus to be about 22 million years ago.

This study shows that AAV-Tnnt2 vectors leak into the liver, reducing cardiac specificity, and demonstrates that adding miR122 target sequences reduces this leakiness.

This study shows that post-transplant G-CSF administration impairs engraftment of CRISPR-edited HSPCs by worsening the p53 DNA damage response, but not unedited or lentiviral-transduced HSPCs.

This paper shows recombinant outer membrane vesicles with cytokines enhance immune responses and H. pylori clearance in mice compared to traditional adjuvants.

The paper identifies Raf13 and IREH1 as growth-promoting kinases suppressed by PP2A under drought stress, modulating the growth-stress trade-off in Arabidopsis.

The paper identifies divergent iron-regulatory states in triple-negative breast cancer cells that correlate with invasive and non-invasive phenotypes and predict patient outcomes.

The paper analyzes genomic, metabolic, and ecological data from nearly all Saccharomycotina yeast species to show that intrinsic genetic factors, not trade-offs or extrinsic factors, drive variation in niche breadth.

The paper develops a machine learning framework to create organ-specific gene expression datasets and infer gene regulatory networks, achieving high accuracy in predicting transcription factors regulating organ-specific processes.

SoyDNGP is a deep learning framework for genomic prediction in soybean breeding that outperforms existing methods in accuracy and efficiency, with a web interface for trait prediction and lookup.

This study shows that H3.3-G34R mutations reprogram the tumor immune microenvironment in diffuse hemispheric gliomas, enhancing the efficacy of immune stimulatory gene therapy and leading to long-term survival in treated mice.

This study shows that ZFP318 regulates mitochondrial function in memory B cells, enhancing their recallability and vaccine potency.

This study identifies an Il-9-Zbtb18 axis that promotes the development of memory B cells from germinal centers by regulating cell cycle, survival, and GC exit.

This study identifies a conserved binding pocket in class B GPCRs that enables small molecule agonists like PCO371 to activate G proteins without triggering arrestin signaling.

This study shows that sustained store-operated calcium entry (SOCE) and chromatin accessibility in iTregs lead to phenotypical instability, unlike tTregs.

This study develops a genetically encoded redox-responsive collagen-like protein hydrogel that accelerates diabetic wound healing by enhancing cell viability and reducing oxidant stress.

This study develops an AI system using robotic dogs to detect red imported fire ant nests with 95% precision, improving surveillance and pesticide delivery in open fields.

This paper identifies ABI1 as an epigenetic regulator of transcriptional homeostasis in AR-driven cancers through novel DNA and AR binding mechanisms.

This study isolates a novel aerobic denitrifying strain, Achromobacter xylosoxidans GR7397, and demonstrates its efficient nitrate removal capacity under optimized conditions.

This study shows that time-restricted feeding alters gut microbiota guilds, which are linked to metabolic improvements in high-fat diet-fed mice.

This study shows that Spineless, the Drosophila AHR homolog, limits tumor growth and stem cell proliferation in the adult intestine by regulating gene expression and metabolism.