Y. Li

This study shows that Disulfiram reduces pulmonary fibrosis by reactivating COX-2-mediated PGE2 synthesis in both cell and animal models.

This study shows that targeting FAP+CAFs in desmoplastic pancreatic tumors reduces stromal barriers, enhances T cell infiltration, and improves response to immunotherapy.

The paper identifies a novel MCR-1 variant with low β-lactam co-resistance and shows synthetic peptides from this variant have broad-spectrum antimicrobial activity.

This study shows that dietary calcium affects calcium content and transporter mRNA expression in mosquito Malpighian tubules, with dynamic changes during blood feeding.

This study shows that early microbial intervention in newborn calves reduces diarrhea and improves later milk production by altering gut microbiome composition and metabolite profiles.

The paper shows that dietary metabolites enhance CD8+ T-cell immunity against Cryptosporidium infection in mice by activating the AHR pathway.

This study presents haplotype-resolved genomes of triploid bananas, revealing subgenome asymmetric evolution and resistance mechanisms against banana wilt.

The paper shows that expanded intronic TNR repeats in IIL1 cause growth defects in Arabidopsis by increasing intron-retained transcripts and disrupting protein interactions essential for leaf development.

This study shows ANKRD49 promotes metastasis in NSCLC cells by activating the JNK-ATF2/c-Jun-MMP-2/9 pathway.

This study demonstrates that exosomes delivering nanogram amounts of SARS-CoV-2 Spike protein induce potent neutralization against Delta and Omicron variants and enhance T cell responses.

This study shows that Notch1's N1ICD forms transcriptional condensates via phase separation coupled percolation, enhancing target gene expression and enhancer looping.

This study shows that tolcapone causes embryo lethality and preeclampsia-like phenotypes in mice by inhibiting trophoblast migration and invasion.

This study identifies HIF2/ARNT as a protective axis in cardiac endothelial cells post-MI, preventing vascular leakage and inflammation through suppression of IL6.

This study identifies an amino acid difference that stabilizes interdomain interactions in Gi1 but not Gi2, leading to differences in effector activation and signaling specificity.

The paper develops a digital diagnostics platform using NFC-enabled potentiostat and nitrocellulose-based electrodes for electrochemical detection of pathogens at the point-of-need.

The paper identifies RipBH, a virulent type III effector from Ralstonia solanacearum, which induces autophagy-associated cell death and is essential for potato brown rot pathogenesis.

This study maps the dynamic multicellular ecosystem of radiation-induced intestinal injury using single-cell RNA sequencing, revealing heterogeneous radiosensitivities and cellular interactions.

This paper introduces a new spectroscopic imaging method that improves signal intensity by over 500-fold for chemical imaging.

This study characterizes the pharmacological response of the GRABeCB2.0 sensor to endocannabinoids and cannabinoids, finding that its EC50 values for 2-AG and SR1 match CB1R potencies, while others show lower EC50s, and CBD acts as a negative allosteric modulator.

This study shows that the type VI secretion system in Geobacter metallireducens affects DIET by altering gene expression and electron transfer efficiency.

This study identifies Fkbp5 as a regulator of epithelial cell quiescence-proliferation transition via Akt signaling in zebrafish using transcriptomics and genetic approaches.

The paper evolves haploid and diploid yeast populations in different environments and finds common, unpredictable pleiotropic effects of adaptive mutations in non-home environments.

The paper identifies cGLRs as a widespread family of pattern recognition receptors in animal innate immunity and elucidates their conserved signaling mechanisms.

This study identifies the ATM-E6AP-MASTL axis as a timer-like mechanism that ensures the transient DNA damage checkpoint by promoting cell cycle recovery.

The paper develops a high-throughput platform for screening functional neo-antigens and their specific TCRs using droplet microfluidics and DNA barcoding.

This study characterizes 52 patient-derived glioma cell lines with whole-genome sequencing, RNA-seq, and drug response screening, identifying three subtypes and their drug sensitivities and tumorigenic potential.

This paper develops robotic fibers (fiberbots) that enable high-precision motion through thermal expansion, demonstrating scalability and integration with medical devices for potential applications in surgery and biomedical engineering.