Y. Li

This study identifies glucocorticoid receptor activation in NK cells as a mechanism driving AREG-mediated immunosuppression in skin cancer, with therapeutic implications.

The paper introduces the colocatome, a spatial-omic framework, to compare microenvironment features between tumour-stroma assembloids and lung cancer specimens, finding that fibroblasts protect cancer cells from treatment by reorganizing cytoarchitecture.

This study shows that commercially available antibodies for detecting PANX1 tyrosine phosphorylation are nonspecific and that Src does not phosphorylate these sites in heterologous systems.

The paper combines environmental DNA and remote sensing to map arthropod biodiversity at fine spatial scales, revealing patterns in species richness and conservation value.

This study reveals the catalytic mechanism of METTL3-14 by identifying two adenosine binding conformations, the methyl transfer transition state, and the roles of key residues in catalysis.

This study shows CLDN2 upregulation during pancreatitis limits disease progression by enhancing tight junction-controlled fluid transport in pancreatic ductal epithelium.

This study identifies a mechanism where cytoskeletal activation of NHE1 drives secondary volume increase and affects cell proliferation in response to hypotonic stress.

This study shows that sequential early-life viral infections in mice reduce antibody responses to SARS-CoV-2 vaccination while altering immune cell profiles and gut microbiota.

This study identifies FAM111A as a restriction factor for vaccinia virus and MVA, showing it degrades viral DNA-binding protein I3 and is counteracted by SPI-1.

The paper compares genome evolution patterns between aphids and phylloxera, finding distinct X chromosome features despite similar reproductive modes.

This study uses deep mutational scanning to analyze the functional constraints and evolutionary potential of the influenza A virus PB1 protein by measuring replicative fitness across most possible amino acid substitutions.

This study shows that palmitic acid induces mTORC1 activation via Tip60-mediated Rheb acetylation, leading to insulin resistance, while unsaturated fatty acids do not.

This study identifies progressive plasticity in colorectal cancer metastases, showing reprogramming into fetal progenitor states and divergent differentiation, linked to poor survival.

This study shows that oxytocin reduces colitis and CAC by enhancing MUC2 fucosylation via OXTR, suggesting it as a potential therapeutic for these conditions.

The paper uses molecular dynamics simulations and cell culture experiments to study how the D55 residue in CLDN15 affects ion size and charge selectivity in tight junctions.

This study characterizes DCAF12 interactions with MAGEA3 and CCT5 degrons using biophysical assays and cryo-EM, revealing key residues for degron recognition and informing PROTAC design.

This study shows that rhamnolipids combined with linezolid synergistically enhance antibacterial activity against linezolid-resistant Enterococcus faecium through multiple assays and mouse models.

This paper describes an in vitro biotransformation pathway using two decarboxylases to convert -alanine to {beta}-alanine with 100% carbon atom economy by fixing CO2.

This study analyzes microbial diversity and metabolic functions in two salt lakes on the Qinghai-Tibet Plateau using metagenomics, revealing differences in microbial composition and salinity adaptation strategies.

The paper determines cryo-EM structures of RNA capping enzymes bound to paused transcription complexes, revealing their direct interaction and mechanism of pre-mRNA capping during transcription.

This paper reviews AI applications in paleontology, highlighting a gap between paleontological AI and mainstream AI studies, and discusses future directions for integrating AI into paleontological research.

This study shows that mtDNA released by senescent cells triggers immunosuppression via PMN-MDSCs, and inhibiting this pathway enhances therapy-induced senescence in cancer.

This study identifies BcGSTF10 as a gene that balances cold stress tolerance and growth in plants, offering insights for breeding climate-resilient crops.

This paper models clathrin-mediated endocytosis to show that the switch between productive and abortive CCPs is an emergent property of clathrin-membrane interactions and EAPs.

This study shows ADAR2 inhibits ER-targeted mRNA translation by regulating SRP assembly in the nucleolus without requiring RNA binding or A-to-I editing.

The paper shows that dMMR tumor cells are resistant to membrane damage but sensitive to IFN-γ and TNF-α co-treatment inducing PANoptosis, suggesting a strategy to enhance ICB therapy.

This study develops a human endometrial assembloid model that mimics the receptive endometrium during the implantation window, showing structural and molecular features and hormone responsiveness.

The paper uses a physics-based model to show how polarized ion carriers and environmental gradients affect intracellular pH, electric potential, and cell movement.

The paper identifies a novel mechanoadaptive process in intervertebral discs through collagenesis, revealing TRPV4's role in collagen II synthesis and mechanical stress adaptation.