Y. Lu

This study shows that fibronectin-coated biomaterials can rescue matrix and cellular defects in fibroblasts with collagen IV mutations.

This paper isolates a third Desulfoluna strain capable of organohalide respiration and characterizes its genetic and metabolic capabilities for dehalogenation.

The paper develops a method to measure multiscale chromatin folding and nuclear structures in single cells, revealing cell-type-specific architectures and physical principles of chromatin organization.

This study identifies structural instability and divergence from conserved residues as causes of intracellular retention of odorant receptors, using computational and experimental methods.

This study examines testosterone level changes in female giant pandas during estrus and finds that testosterone peaks 4 days after estradiol peaks and is only correlated with estradiol after the estradiol peak.

The paper investigates chloroform biotransformation in hypersaline sediments using cultivation and metagenomic approaches, finding that Clostridiales likely mediate CF to DCM and CO2 conversion.

This paper introduces a drug discovery platform called SPEED that uses epitope editing to screen small molecules for altering antibody-epitope interactions and validates its application for Aβ species.

This study develops an anti-somatostatin receptor 2 antibody-drug conjugate (ADC) that effectively targets and kills neuroendocrine tumors with minimal toxicity.

The paper quantifies biodiversity-driven productivity gains in non-rice crops in Asia-Pacific, showing biological control provides annual benefits of $22.6 billion and yield-loss recovery of 73-100%.

The paper investigates how hypoxia-induced oxidative stress affects neuroglia, astrocyte reactivity, and myelin production using a 3D hydrogel system in a microfluidic device.

The study evaluates bacterial contamination of computer equipment in a hospital, finding mouse pads are highly contaminated and require daily cleaning.

This study shows that fatty acids enter FABP via local unfolding of helix 2, not gap widening, using a gap-closed variant and biophysical experiments.

The paper identifies a genomic region Lyb-2-4 associated with hypervirulence in carbapenem-resistant Acinetobacter baumannii, showing higher mortality in infected patients and mice.

This study shows that p16 suppression increases nucleotide synthesis through mTORC1 activation, promoting tumorigenesis by bypassing senescence.

This study isolates putative S-layer proteins from anammox biofilm extracellular matrix using ionic liquid extraction and identifies them as major structural components.

This study shows TAZ uses phase separation to compartmentalize transcription factors and enhance gene expression, distinct from its paralog YAP.

The paper compares gut metagenomics and metaproteomics in prediabetics and treatment-naïve type 2 diabetics to identify host-microbial interplays across disease stages.

This study investigates how cholesterol levels in red blood cells affect malaria parasite invasion, finding no significant impact from serum cholesterol but suggesting genetic variations in membrane lipid composition may influence susceptibility.

The paper identifies a circadian mechanism regulating collagen synthesis, assembly, and degradation to maintain tissue homeostasis in mice.

The Tcb1-female gene encodes a Pectin Methylesterase that in teosinte silks prevents fertilization by maize pollen.

The paper assesses how colorful bird feathers appear to mammalian predators using visual modeling, finding they are often cryptic to these predators but visible to birds.

The paper develops a microchip-based sequential secretion assay to analyze protein dynamics in single human macrophages, revealing distinct activation modes and states dependent on basal conditions.

This paper develops a platform to multiplex profile single-cell EV secretion, revealing heterogeneity in EV phenotypes and secretion patterns in OSCC cells.

This study compares the venom effectiveness of fire ant queens and workers, finding queen venoms act faster to knock down competitors than worker venoms.

The paper presents cryo-EM structures of the human 26S proteasome in seven conformational states during polyubiquitylated protein degradation, revealing dynamic substrate-proteasome interactions and ATP hydrolysis mechanisms.

The paper analyzes the distribution and genetic diversity of ammonia-oxidizing archaea (AOA) lineages in global oceans using metagenomics data, revealing distinct ecological patterns and environmental correlations.

The paper identifies a voltage-gated potassium channel in African mormyrid electric fish that evolves under positive selection and modifies action potential duration through unique biophysical properties.

This study shows that liraglutide reduces obesity-induced kidney injury by restoring renal lipid and energy metabolism through metabolic and molecular mechanisms.

The paper examines whether artificial selection for domestication traits in maize and sorghum targets orthologous genes, finding that while some genes show parallel selection, most targeted genes are non-overlapping.