Y. Wu

This study identifies BrrRCO, a HD-Zip transcription factor, as a key gene regulating leaf lobe development in Brassica rapa, with cis-regulatory variations affecting its function and leaf shape.

This study shows human monocytes form patterned multicellular domains on soft matrices through local adhesion and global inhibition, with a computational model validating the mechanism.

This study examines the competitive fitness and homologous recombination of SARS-CoV-2 variants in vitro, showing cell-specific fitness differences and recombination hotspots.

This paper identifies AMPK's role in shifting carbon utilization from glucose to glutamine via PDZD8 phosphorylation, enhancing glutaminolysis and extending lifespan in C. elegans and mice.

This study identifies a Sorcin-STAT3-Serpin E1/CCL5 signaling axis that drives pancreatic cancer-associated new-onset diabetes by impairing beta-cells and elevating serpin E1 levels in peripheral blood.

This study designs a SARS-CoV-2 protease inhibitor with improved affinity and reduced mutation sensitivity compared to existing drugs.

This paper presents a neural stimulator and intraneural electrode for selective vagus nerve stimulation, demonstrating selective modulation of physiological functions in pigs.

This study identifies differentially expressed proteins in A. acidoterrestris under sublethal pH stress, revealing key acid resistance mechanisms involving pH homeostasis, metabolism, and DNA repair.

The paper identifies kinesin-1 and RIC-7 as polarized transport complexes at the leading end of mitochondria driving anterograde axonal transport in C. elegans.

This study presents cryo-EM structures of FZD6, FZD3, and FZD1 in active and inactive states, revealing a shared activation framework and potential crosstalk between G-protein binding and Wnt-PCP signaling.

The paper introduces aSRRF, a method that enhances SIM resolution to ~50 nm isotropically using image augmentation without changing the optical setup or sample acquisition.

This study investigates how inosine inhibits Alicyclobacillus acidoterrestris by damaging its cell membrane and affecting DNA replication and energy metabolism.

This study shows that 2-Bromopalmitate inhibits coronavirus replication by disrupting lipid droplets, not through palmitoylation inhibition.

This paper develops FUS-CRISPR(a/i) tools to remotely control gene expression and epigenetic modifications in vivo, showing therapeutic effects in tumor models.

The paper quantifies sinking velocities of unicellular algae to show their dependence on cell size, light, and nutrients, revealing mechanisms linking cell composition to vertical movement.

This study shows that NVP-HSP990, a HSP90 inhibitor, effectively reduces rotavirus infection in vitro and in mice by inhibiting replication and alleviating intestinal damage.

This study shows that the KDELR/Erd2-mediated ER retrieval system regulates UPR and AMPK signaling to maintain cellular homeostasis by affecting mitochondrial respiration and ROS levels.

This study shows that Ascaris suum larvae hatch in the host stomach, not the small intestine, using gastric acid and AMCase, and demonstrates that inhibiting these factors reduces parasitic burden and lung disease.

This study uses multiscale computational simulations to model T cell engagement by bispecific antibodies, identifying strategies to enhance efficacy and reduce off-target effects.

The paper shows co-infecting phages impede each other's entry into cells, revealing MOI-dependent host physiological changes that affect infection outcomes.

The paper presents cryo-EM structures of Kv1.2 potassium channels in different states, revealing new insights into selectivity filter stability and toxin block mechanisms.

This study investigates how ATP hydrolysis by MDA5 and LGP2 influences viral RNA sensing, showing MDA5's selectivity and LGP2's role in modulating MDA5 filament assembly.

The paper identifies eIF3k as a regulator of ribosome content in cancer by showing its depletion increases global translation and stress resistance through repression of RPS15A synthesis.

This study introduces DeepT2, a machine learning model that predicts type II polyketides from KS{beta} sequences without alignment, using NLP techniques and metagenomics/metabolomics data.

This study identifies Xosr001, an sRNA packaged in OMVs of Xoc, as a mediator of stomatal immunity in rice by modulating OsJMT1 and MeJA levels.

This paper introduces a computational framework using spatio-temporal atlases to establish normative trends in perinatal structural brain connectivity from diffusion MRI data.

The paper shows that evolution in Pseudomonas aeruginosa populations selects for cheater mutants that modify social cooperation to stabilize chronic infections and reduce host immune response.

This study identifies RNA sensing and innate immunity in host embryos as a barrier to interspecies chimerism and shows that modifying host embryos can enhance human cell survival in chimeric embryos.

This paper introduces a self-healing PDMS material with safety-enhancing properties for wireless, skin-interfaced bioelectronic devices.

The paper characterizes the Kiwa defence system as a bacterial membrane supercomplex that detects phage-induced membrane changes and inhibits phage replication.