Author

T. Su

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 2 Plant Biology· 2 Bioengineering· 1 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:cell type annotation· 4 Research Focus:differential expression· 3 Organism:human· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Assay:proteomics· 2

Frequent Co-Authors

H. Yang· 2 shared M. Gong· 2 shared S. Wang· 2 shared W. Zhao· 2 shared Y. Chen· 2 shared Y. Zhang· 2 shared A. A. Nickson· 1 shared A. J. Simmons· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiochemistry

H. Yang

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10 papers

Recent·Most cited

BrrRCO, encoding a homeobox protein, is involved in leaf lobe development in Brassica rapa

P. Li, T. Su, Y. Wu, H. Li, L. Wang, F. Zhang, S. Yu, Z. Wang

This study identifies BrrRCO, a HD-Zip transcription factor, as a key gene regulating leaf lobe development in Brassica rapa, with cis-regulatory variations affecting its function and leaf shape.

bioRxiv · Aug 2, 2023 · PreprintPlant Biology

Engineering cGAS-agonistic oligonucleotides as therapeutics and vaccine adjuvants for cancer immunotherapy

S. Zhou, T. Su, F. Cheng, J. Cole, X. Liu, B. Zhang, S. Alam, J. Liu, G. Zhu

This paper develops Svg3, a cGAS-agonistic oligonucleotide, showing enhanced IFN-I responses and improved immunotherapy efficacy in preclinical models.

bioRxiv · Jul 13, 2023 · PreprintBioengineering

Ancient DNA in Lycoptera Fossils: Key Discoveries for Evolution and Methodological Reassessment

W. Zhao, Z. Guo, Z. Tian, T. Su, G. Cao, Z. Qi, T. Qin, W. Zhou, J. Yang, M. Chen, X. Zhang, C. Zhou, C. Zhu, M. Tang, M. Tang, , S.-J. Zhang

The paper extracts and analyzes ancient DNA from Lycoptera davidi fossils, identifies original DNA fragments, and introduces a new method for aDNA analysis and a novel genomic mechanism.

bioRxiv · Jun 18, 2023 · PreprintPaleontology

Proteomic Landscape of Human Spermatozoa: Optimized Extraction Method and Application

M. Luo, T. Su, S. Wang, J. Chen, Q. Cheng, T. Lin, Y. Chen, M. Gong, H. Yang, F. Li, Y. Zhang

This study optimizes protein extraction methods for human sperm and investigates antibiotic effects on sperm proteome, finding increased concentration and malformed sperm with altered proteome expression.

bioRxiv · Nov 25, 2022Biochemistry

Orchestration of alternative splicing regulates bone marrow mesenchymal stem cells fate during aging

Y. Xiao, G.-P. Cai, X. Feng, Q. Guo, Y. Huang, T. Su, C.-J. Li, X.-H. Luo, Y.-J. Zheng, M. Yang

This study identifies YBX1 deficiency causes mis-splicing in BMSCs, leading to senescence and bone loss, and shows Sciadopitysin can reverse this process.

bioRxiv · May 27, 2022 · PreprintCell Biology

Coupling Comprehensive Transcriptome-Metabolome Association and Phylogenetic Analysis Speed Dissecion of Polyphyllins Biosynthetic Pathway

x. hua, W. Song, K. Wang, X. Yin, c. Hao, B. Duan, Z. Xu, T. Su, z. Xue

This study identifies key genes in the polyphyllin biosynthetic pathway using transcriptome and metabolome data combined with phylogenetic analysis.

bioRxiv · Feb 1, 2021Plant Biology

Human colorectal pre-cancer atlas identifies distinct molecular programs underlying two major subclasses of pre-malignant tumors

B. Chen, E. T. McKinley, A. J. Simmons, M. A. Ramirez, X. Zhu, A. N. Southard-Smith, N. O. Markham, Q. Sheng, J. Drewes, Y. Xu, C. N. Heiser, Y. Zhou, F. Revetta, L. D. Berry, W. Zheng, , K. Lau

The paper creates a single-cell atlas of colorectal pre-cancerous polyps, identifying distinct molecular programs in adenomas and sessile serrated lesions and their associations with CRC subtypes.

bioRxiv · Jan 11, 2021Cancer Biology

Site-specific N-glycosylation Characterization of Recombinant SARS-CoV-2 Spike Proteins

Y. Zhang, W. Zhao, Y. Mao, Y. Chen, S. Wang, Y. Zhong, T. Su, M. Gong, D. Du, X. Lu, J. Cheng, H. Yang

The paper characterizes site-specific N-glycosylation of SARS-CoV-2 spike proteins expressed in human and insect cells, revealing differences in glycan types and their implications for infection and vaccine development.

bioRxiv · Mar 28, 2020Biochemistry

Single-cell transcriptomics reveals zone-specific alterations of liver sinusoidal endothelial cells in cirrhosis

T. Su, Y. Yang, S. Lai, J. Jeong, Y. Jung, M. McConnell, T. Utsumi, Y. Iwakiri

This study uses single-cell RNA sequencing to identify zone-specific transcriptomic changes in liver sinusoidal endothelial cells in cirrhosis, revealing Zone 3 LSECs as most susceptible to damage.

bioRxiv · Mar 18, 2020Cell Biology

The Folding Pathway of an Ig Domain is Conserved On and Off the Ribosome

P. Tian, A. Steward, R. Kudva, T. Su, P. J. Shilling, A. A. Nickson, J. J. Hollins, R. Beckmann, G. Von Heijne, J. Clarke, R. Best

The paper shows that the folding pathway of the titin I27 domain is conserved whether folding occurs on or off the ribosome.

bioRxiv · Jun 18, 2018Biophysics