Z. Li

This study identifies an insertion sequence in SARS-CoV-2 spike protein that enhances cleavage efficiency and expands tissue tropism beyond the lungs.

This study shows that RAS activation via CRLF2 signaling is common in DS-ALL regardless of RAS mutations and is predictive of poor outcomes.

This paper introduces A-Star, a method for detecting rare mutations with high sensitivity and multiplexing capability, achieving detection as low as 0.01% allele frequency.

This study identifies ACE2-expressing cells in the digestive system using single-cell transcriptomes, suggesting the digestive tract as a potential route for 2019-nCov infection.

This study develops a red-light optogenetic system to noninvasively control Drosophila cardiac rhythms, showing improved efficiency and lower power requirements compared to blue light.

The paper identifies genetic factors underlying pelvic reduction in sticklebacks and shows how population structure limits local adaptation.

The paper identifies a phospho-switch mechanism in NRT2.1 where phosphorylation at S21 and S28 modulates its interaction with NAR2.1 and NURK1, affecting nitrate uptake.

The paper presents cryo-EM structures of Nav1.5 bound to tetrodotoxin and quinidine, revealing mechanisms of pore blockade and disease mutation mapping.

This study shows NDRG2 maintains intestinal epithelial barriers by regulating E-cadherin and adherens junctions, preventing colitis and tumor development.

This study shows cancer reduces insulin-stimulated glucose uptake in muscle and adipose tissue and impairs muscle microvascular perfusion in mice.

The paper introduces a light-mediated proximal labeling strategy for organelle-specific protein profiling in living cells, using commercially available reagents and avoiding exogenous gene transduction.

The paper investigates correlated evolution of large DNA fragments in the 3D genome of Arabidopsis thaliana, showing that spatially interacting fragments exhibit similar polymorphism and evolutionary rates.

The paper identifies key regulators of BRAF inhibitor resistance in melanoma using CRISPR screens and integrates multi-omics data to reveal CDK6-dependent mechanisms.

Track-Control provides an automated real-time closed-loop system for behavioral assays, enabling efficient and flexible control of experimental conditions.

This study demonstrates that transient expression of Runx1 and Hoxa9 in pluripotent stem cells generates functional T cells capable of immune surveillance and tumor eradication.

This study shows two TYK2 variants affect exon splicing and mildly enhance TYK2 expression, potentially contributing to autoimmune diseases.

This paper identifies a stepwise endonuclease activity in PfAgo that enables multiplex gene detection through a platform called RADAR, applied to distinguish human papillomavirus serotypes.

The paper reports the structure of arrestin-2 bound to neurotensin receptor 1, revealing a novel orientation that enables coupling to GPCRs lacking a C-terminal tail.

This study evaluates how adding Chinese herbal medicine residues affects antibiotic resistance genes and bacterial communities in chicken manure composting, finding increased ARG removal with higher residue addition.

The paper identifies neutrophil cytokine response profiles as prognostic markers in tuberculosis and cancer by analyzing myeloid cell transcriptional responses to various cytokines.

This study shows that bacterial flagella are not permanent structures, dynamically produced and lost during growth phases, with glucose availability influencing their disassembly.

RhizoVision Crown is an open-source platform for high-throughput root crown phenotyping in crops, validated with simulated images and used on soybean and wheat, showing species-specific heritability.

The paper investigates the solution structure of overlapping dinucleosomes using SAXS, SANS, modeling, and simulations, showing histone tails stabilize their conformations.

This study finds that combining minimum tillage with residue retention in double cropping systems most effectively increases soil carbon storage.

This study shows that desmin deletion in Mdx mice worsens muscle weakness, fragility, and fatigue resistance, while desmin gene transfer improves these features.

The paper reports that ORF2p expression is undetectable in human cancers despite high ORF1p expression and somatic L1 retrotransposition.

The paper identifies Bacteroides ovatus strains that induce IgA production and shows that manipulating these strains can modify gut IgA levels in mice.

This study examines how small genomic introgressions affect plant traits across different environments, finding significant allele-by-environment interactions in various growth stages.

The paper reveals how E7820 promotes RBM39 degradation via DCAF15 by binding to a non-conserved pocket on DCAF15, bypassing the need for high-affinity ligands.

The paper infers 244 putative ancient whole genome duplications across green plants using 1KP transcriptome data and evaluates their consistency with syntenic analyses.