Z. Li

The paper identifies dysbiosis in RA tonsillar microbiota and shows that Streptococcus salivarius and its antibacterial peptides modulate autoimmunity by suppressing T cells and autoantibodies.

This study shows that Crif1 promotes radiation-induced osteoporosis in mice by increasing RANKL expression and that targeting Crif1 could be a therapeutic strategy.

This study designs myristoylated cell penetrating peptides to target the oncogenic K-Ras.G12D protein at the effector binding membrane interface, inhibiting downstream effector interactions.

This study develops an efficient CRISPR/Cas9 method for integrating a large transgene cassette into the CEP112 locus in pigs, achieving successful expression of microbial enzymes in salivary glands.

This study examines the assembly properties of SyFtsZ from Synechocystis sp. PCC 6803, identifying different protofilament structures formed in GTP and GDP conditions.

This study compares the efficacy of new bio-pesticides and conventional chemical pesticides against Tetranychus cinnabarinus, finding abamectin to be the most effective.

The paper analyzes bacterial diversity succession in compost made from pig manure and wood chips using 16S rRNA gene analysis, showing shifts in microbial phyla over composting stages.

This study identifies Xin as a novel protein involved in skeletal muscle disuse atrophy using phosphoproteomic analysis and confirms its regulation in mice and humans.

This study shows that follistatin overexpression in muscle improves insulin-stimulated glucose uptake and protein synthesis, and that circulating follistatin increases after bariatric surgery, suggesting its role in insulin sensitivity.

This study shows that NOX2 produces cytosolic ROS in skeletal muscle during exercise, which regulates glucose uptake and GLUT4 translocation.

The paper shows CDK1 phosphorylates ULK1-ATG13 in mitosis to regulate autophagy and Taxol sensitivity, with implications for cancer therapy.

The paper develops SGC-GAK-1 as an orally active in vivo probe for GAK by using cytochrome P450 inhibition to improve its metabolic stability and plasma exposure.

The paper identifies RET kinase as a targetable driver in neuroendocrine prostate cancer (NEPC) through phosphoproteomics and pharmacological inhibition studies, showing reduced tumor growth in models.

This paper introduces a microfluidic chip that improves single-cell encapsulation efficiency by fourfold, achieving a 3% co-capturing rate with low doublet rates in sequencing data.

This study identifies aroma-active compounds in three delicious apple juice cultivars using GC-MS, GC-O, and OAV, finding key contributors to the juice's aroma.

The paper shows that PNP-A antagonizes SA-mediated cell death in Arabidopsis lsd1 mutants by interacting with a newly identified receptor PNPAR.

This study shows that the I232T SNP in FcγRIIB causes structural changes that reduce ligand binding, contributing to SLE pathogenesis.

The paper develops a biomaterial platform to control immune cell activity by modulating protein ratios on biodegradable particles, enhancing cancer immunotherapy efficacy and safety.

The paper identifies a phosphorylation site in NRT2.1 that inactivates its nitrate uptake function in Arabidopsis thaliana, revealing a regulatory mechanism modulated by nitrate.

This study investigates the selectivity of 4-aminoquinolines for the alpha2A-adrenoceptor using docking, molecular dynamics, and mutagenesis to identify binding sites and affinity determinants.

This paper identifies HMGA2 as a regulator of DNA supercoiling and replication fork stability, showing its protective role against DNA damage from topoisomerase poisons and its potential as a therapeutic marker in cancer.

This study shows that NOX2 is necessary for skeletal muscle adaptations to high-intensity interval training, including antioxidant defense and mitochondrial changes.

This study identifies OsCYP71D8L as a regulator of gibberellin and cytokinin homeostasis in rice, affecting growth and stress tolerance.

This study identifies DDR1 as upregulated in ADPKD but shows it does not contribute to disease progression, ruling it out as a therapeutic target.

This paper elucidates the compartmentalized biosynthetic pathway of mycophenolic acid, revealing subcellular localization of enzymes and cooperation with β-oxidation machinery.

This study shows low-dose IFN-γ promotes tumor stemness in NSCLC via ICAM1-PI3K-Akt-Notch1 pathway, while high-dose IFN-γ induces apoptosis through JAK1-STAT1-caspase pathway.

This paper designs multi-furcating microfluidic channels for efficient droplet splitting and investigates splitting regimes and breakup mechanisms.

This paper establishes a multilocus sequence analysis (MLSA) method using six protein-coding genes to classify Shewanella strains, revealing evolutionary relationships and population biology.

The paper investigates the Prp8 intein in Cryptococcus neoformans, showing that copper and zinc inhibit intein splicing through distinct mechanisms, potentially affecting spliceosome function.

This study demonstrates that tungsten oxide nanodots exhibit strong antibacterial activity against both gram-negative and gram-positive bacteria, with enhanced efficacy under sunlight exposure and confirmed biocompatibility.