Z. Li

This study compares the binding of SARS-CoV-2, SARS-CoV, and MERS-CoV spike proteins to glycans, finding HS binding is sulfation-dependent and sialic acid binding is absent.

This study uses single-cell RNA-seq to analyze keloid tissue and identifies lineage-specific regulatory changes in fibroblasts and vascular endothelial cells, highlighting key pathways and potential therapeutic targets.

This study shows that Bcl6 deletion in Treg cells reduces tumor growth by impairing their suppressive function, and increased Bcl6 expression is linked to poor cancer outcomes.

This study develops a vaccine candidate against SARS-CoV-2 using virus-like particles displaying the receptor binding domain, which induces neutralizing antibodies in mice.

The paper identifies lipid droplet-like structures in gut microbiota from mouse and human samples and establishes a method to study them.

The paper maps a comprehensive cytokine gene regulatory network using eY1H assays, identifying 1,380 TF-cytokine gene interactions and novel regulatory axes in immune diseases.

The study introduces a new PET radiotracer for profiling tumor protein oxidation as a prognostic indicator of resistance to radiation therapy.

This study identifies HK2 as a marker for detecting underrepresented CTCs in NSCLC, revealing a distinct subpopulation with unique characteristics.

The paper shows that inactivating the TN/TX microRNA-degrading enzyme in mice causes adiposity similar to Tsn deletion, but cell-specific deletion does not replicate this effect.

This study shows that filamentous viral particles have a functional advantage over spherical ones in resisting neutralizing antibodies and fusion inhibitors.

This paper reports the cryo-EM structure of the C9ORF72-SMCR8-WDR41 complex, revealing its role as a GAP for Rab8a and Rab11a.

This study develops and evaluates porous scaffolds combining HA, PLGA, and MSM for bone defect reconstruction, showing improved cell adhesion, proliferation, and drug release properties.

The paper identifies sex differences in CD8+ T cell programming in bladder cancer, showing male-biased T cell exhaustion and implications for immune checkpoint therapy.

The paper identifies bHLH11 as a negative regulator of Fe homeostasis in Arabidopsis, showing it inhibits bHLH IVc transcription factors by recruiting TOPLESS/TOPLESS-RELATED corepressors.

The paper identifies ArlCDE as the archaeal switch complex that mediates chemotaxis signal transduction to the archaellum in Haloferax volcanii.

This study shows that ER mutations in breast cancer cells cause gene expression changes through constant activity and secondary effects, not just ligand independence.

This study examines risperidone-induced DNA methylation changes in first-episode schizophrenia patients and links them to neuroimaging and cognitive phenotypes.

This study identifies a negative feedback loop involving NR4A receptors that limits B cell proliferation without T cell help and enhances antibody responses to T-independent antigens.

The paper compares silicone and cotton swabs for RNA extraction in COVID-19 testing, finding silicone swabs yield higher RNA concentration and quality.

This paper introduces a dynamic aqueous multiphase reaction system for rapid, sensitive, and quantitative CRISPR-Cas12a-based molecular diagnosis of HPV16/18 DNA.

The paper introduces AIOD-CRISPR, a dual CRISPR-Cas12a assay for rapid, ultrasensitive, and visual detection of SARS-CoV-2 and HIV with high sensitivity comparable to RT-PCR.

The paper proposes a mathematical framework to quantify fungal and bacterial inorganic nitrogen immobilization rates in soil using measurable data and proxies.

This study analyzes exome sequencing data from paired primary tumors and metastases to investigate clonality and timing of metastatic spread across cancers.

This paper reanalyzes CT scan data of Oculudentavis and concludes it is a squamate, not a bird or archosaur, based on morphological evidence.

This paper develops an AI tool for colorectal cancer diagnosis using histopathology images, achieving high accuracy and consistency across multiple centers.

The paper uses isotope tracing to compare metabolism between cancer cells and fibroblasts in pancreatic tumors, identifying key metabolic dependencies in cancer cells.

This study shows caloric restriction inhibits tumor growth by reducing lipid availability and impairing stearoyl-CoA desaturase activity in cancer cells.

This study analyzes smoking-induced changes in the tumor immune microenvironment across ten cancer types using TCGA data, finding increased plasma cells and altered immune cell ratios linked to survival outcomes, with stronger effects in female smokers.

This study uses a CRISPR screen in mouse Tregs to identify genes regulating Foxp3 expression, finding Usp22 and Atxn7l3 as stabilizers and Rnf20 as a destabilizer.

The paper investigates the genetic basis of rumen evolution by comparing transcriptomes and genomic data across ruminants, camels, and cetaceans, identifying key genetic innovations.