Ian J. Deary

This paper performs a genome-wide association study meta-analysis of AUDIT scores in two cohorts, identifying risk loci and genetic correlations with alcohol consumption and psychiatric disorders.

The paper applies polygenic risk scoring to a large family with bipolar and depressive disorders to study genetic risk patterns and anticipation.

The paper develops DNA methylation predictors for BMI, smoking, alcohol, and education, finding they explain some phenotypic variance and predict mortality for some traits.

This study identifies age-related DNA methylation changes in old Swedish twins over 20 years, showing stability across cohorts and genetic influences independent of age.

The paper examines the association between brain peak width of skeletonised mean diffusivity (PSMD) and cognitive domains, finding it correlates with processing speed but not more strongly than other brain imaging measures or cognitive domains.

The paper examines resting-state brain connectivity in UK Biobank data and finds associations with cognitive performance, educational attainment, and household income.

This study identifies 206 new genomic loci and 1,041 genes associated with intelligence using a large GWAS meta-analysis of 279,930 individuals.

This paper identifies genetic loci associated with retinal vascular tortuosity and links one of them to coronary artery disease risk.

The paper identifies gene targets for brain-related traits using transcriptomic and methylomic data from blood, finding strong correlations between genetic effects in brain and blood tissues.

This study examines the association between polygenic risk scores for neurodegenerative disorders and cognitive performance, finding lower cognitive performance with higher risk scores for AD, ALS, and FTD.

This study identifies six new Alzheimer's disease-associated loci using GWAS on family history data from UK Biobank and consortium data, with potential implications for precision medicine.

Genome-wide association meta-analysis of 130,664 major depression cases and 330,470 controls identifies 44 independent risk loci enriched in cortical neurons, conserved mammalian regions, splicing networks, and antidepressant targets.

Structural equation modeling over GWAS summary statistics fits several traits jointly; across five psychiatric traits it surfaced 27 SNPs the univariate GWASs missed and sharpened polygenic scores.

Across 5,216 UK Biobank adults, males had larger brain volumes and surface areas, females thicker cortices and stronger default-mode connectivity; male variance was generally greater.

This study conducts a GWAS on depression phenotypes in UK Biobank, identifying genetic variants enriched in excitatory synaptic pathways.

This study examines the association between polygenic risk scores for Major Depressive Disorder derived from the NETRIN1 pathway and whole-genome variants with white matter microstructure in the UK Biobank.

The paper investigates the genetic and environmental contributions to stressful life events and their overlap with depression and neuroticism using a large family-based sample.

This study identifies 28 genetic loci associated with broadly-defined headache using UK Biobank data, including 14 new loci and 14 previously linked to migraine.

This study uses MTAG to combine GWAS of education and income with a GWAS of intelligence, identifying 107 loci and 233 genes associated with intelligence.

The paper uses family data to estimate genetic effects on intelligence and personality, finding that rare variants explain more variance than previously reported using unrelated individuals.

This study performs genome-wide meta-analyses of depression in two large cohorts, finding one significant locus and suggesting larger sample sizes may be more informative than phenotypic stratification.

The paper examines the relationship between DNA methylation age acceleration and Alzheimer’s disease risk factors, finding significant associations with BMI, cholesterol ratios, socioeconomic status, and smoking behavior.

The paper identifies 116 independent genetic variants associated with neuroticism in over 329,000 UK Biobank participants and finds genetic correlations with mental health traits.

The paper examines the association between APOE e4 genotype and brain structural ageing phenotypes in UK Biobank, finding a significant link with white matter hyperintensity volumes but no age interaction.

This study performs a genome-wide haplotype-based association analysis for major depressive disorder using two cohorts, identifying significant haplotypes potentially linked to the disorder.

This study performs a large-scale GWAS of cognitive ability, identifies 70 genomic loci, and finds tissue-specific gene expression and potential drug targets.

This study finds accelerated epigenetic ageing in major depressive disorder (MDD) cases compared to controls using the Horvath clock, partially mediated through BMI.

The paper matches 73- and 92-year-olds for childhood intelligence, social background, and brain size, finding significant structural brain differences linked to cognitive decline.

This study examines the genetic architecture of trail making test performance and its genetic correlations with cognitive functions in UK Biobank participants.