Magda Tsolaki

Genomics link obesity and type 2 diabetes to Alzheimers disease to unveil novel biological insights

This study links obesity and type 2 diabetes to Alzheimer's disease through genetic and transcriptomic analyses, identifying shared pathways and potential drug targets.

Blood-based multivariate methylation risk score for cognitive impairment and dementia

The paper develops a multivariate methylation risk score using blood DNA methylation data to predict dementia risk and cognitive impairment in Alzheimer's and Parkinson's disease cohorts.

The genetic architecture of human brainstem structures and their involvement in common brain disorders

The paper identifies genetic loci associated with brainstem volumes and finds genetic overlaps with psychiatric and neurological disorders.

Genetics of brain age suggest an overlap with common brain disorders

The paper estimates brain age gaps using MRI and machine learning in individuals with and without brain disorders, finding heritability and genetic overlap with common disorders.

Analysis of shared heritability in common disorders of the brain

Genetic correlations across 25 brain disorders (215,683 cases) reveal broad psychiatric common-variant sharing, largely distinct neurological disorders, and migraine as the only significant cross-category link.

Random Forest Feature Selection, Fusion and Ensemble Strategy: Combining Multiple Morphological MRI Measures to Discriminate among healthy elderly, MCI, cMCI and Alzheimer's disease patients: from the Alzheimer’s disease neuroimaging initiative (ADNI) database

The paper uses a Random Forest-based ensemble strategy to classify four groups of patients using MRI features from the ADNI database, achieving 61.9% accuracy in a blind validation set.