Stephen John Kent

Live attenuated YFV-17D vaccine induces robust B and T cell immunity in vaccine-draining lymph nodes

This study examines immune dynamics in lymph nodes after YFV-17D vaccination, identifying robust B and T cell responses and a conserved germinal center program across different vaccines.

Immunogen selection and prior immunity shape antibody breadth following immunisation with avian H5 hemagglutinin

This study shows that vaccine strain selection and prior immunity influence antibody breadth against avian H5 hemagglutinin in mice.

Epistasis facilitates the long-term antigenic evolution of the influenza B virus hemagglutinin

The paper analyzes the antigenic evolution of influenza B virus hemagglutinin over 8 decades, identifying epistatic networks that balance antigenic novelty with viral fitness.

Pre-existing systemic and nasal antibodies against avian H5 influenza A viruses vary according to childhood imprinting

The paper examines pre-existing antibodies against avian H5 influenza A viruses in individuals born between 1928-1999, showing variations based on childhood exposure and birth year.

High-dimensional multiomics reveals perturbations to IL-6/IL-6R axis and RUNX3 in CD4+ T cells during third trimester pregnancy

This study identifies changes in CD4+ T cell surface proteins and transcriptomes during pregnancy, highlighting perturbations in the IL-6/IL-6R axis and RUNX3 expression.

Defining influenza-specific B cells in vaccine responders, non-responders and influenza breakthrough infections

This study identifies atypical B cell markers associated with influenza vaccine non-responsiveness and severe infection using single-cell transcriptomics.

A novel chimeric coronavirus spike vaccine combining SARS-CoV-2 RBD and scaffold domains from HKU-1 elicits potent neutralising antibody responses

A chimeric coronavirus spike vaccine combining SARS-CoV-2 RBD and HKU-1 scaffold domains elicits potent neutralising antibodies and CD4 T cell help in mice and macaques.

Impact of serum versus anticoagulant-containing plasma on influenza virusneuraminidase-based serological assays

This study compares NA-specific antibody titres in serum and plasma using ELLA and ELISA, finding discrepancies and recommending serum for standardized assays.

Memory T and B cells with recognition of avian influenza hemagglutinins are poorly responsive to existing seasonal influenza vaccines

The paper quantifies pre-existing human B cell responses to avian influenza H5 and H7 hemagglutinins and shows limited boosting by seasonal vaccines.

Deconvoluting TCR-dependent & -independent activation is vital for reliable Ag-specific CD4+ T cell characterization by AIM assay

The paper shows that AIM assays overestimate Ag-specific CD4+ T cells due to TCR-independent activation and introduces a modified assay using CXCR4-CD137+ cells for accurate characterization.

Transiently boosting Vγ9+Vδ2+ γδ T cells early in Mtb coinfection of SIV-infected juvenile macaques does not improve Mtb host resistance.