Stephen H. Hughes

LINE1-mediated reverse transcription and genomic integration of SARS-CoV-2 mRNA detected in virus-infected but not in viral mRNA-transfected cells

The paper detects SARS-CoV-2 retrotransposition into host genomes via LINE1 in infected cells but not in transfected cells, using WGS and TagMap methods.

A reference induced pluripotent stem cell line for large-scale collaborative studies

The paper identifies and characterizes a reference iPSC line, KOLF2.1J, for standardized use in collaborative studies across multiple differentiation protocols and assays.

HIV-1 Viremia Not Suppressible By Antiretroviral Therapy Can Originate from Large T-Cell Clones Producing Infectious Virus

The paper identifies large T-cell clones producing infectious HIV-1 virus as a source of non-suppressible viremia despite ART adherence and no drug resistance.

Reprogramming human T cell function and specificity with non-viral genome targeting

This paper develops a non-viral CRISPR-Cas9 system for precise genome editing in human T cells, enabling therapeutic reprogramming of cell function and specificity.