Rebecca Yunker

A host-adapted commensal fungus from pet store mice drives type 2 immunity and cross-kingdom protection

This study identifies Kazachstania pintolopesii as a commensal fungus in pet store mice that induces type 2 immunity and protects against nematode infection without triggering classical anti-fungal responses.

An IL-17-DUOX2 axis controls gastrointestinal colonization by Candida albicans

This study identifies an IL-17-DUOX2 axis that regulates C. albicans colonization and filamentation in the gut through interactions with candidalysin toxin.

Epithelium intrinsic zinc sensor controls immune homeostasis with gut microbes via regulation of Tuft cell lineage

This study shows that zinc sensing via MTF1 in intestinal epithelial cells regulates Tuft cell lineage and immune homeostasis with gut microbes.

High-throughput Oligopaint screen identifies druggable regulators of genome folding

The paper develops HiDRO, a high-throughput imaging pipeline, to screen the human druggable genome and identifies >300 factors regulating chromatin folding, including GSK3A as a regulator of TAD interactions.

NIPBL and WAPL balance cohesin activity to regulate chromatin folding and gene expression

This study shows that NIPBL and WAPL regulate cohesin activity to control chromatin folding and gene expression, with their relative levels determining transcriptional outcomes.