Swee Lay Thein

Immunoregulatory gene GIMAP6 suppresses lethal atherosclerotic vasculopathy and ischemic heart failure

This study shows that GIMAP6 loss leads to inflammatory vasculopathy and atherosclerosis, causing heart failure and early death, and identifies GIMAP6 as a protective factor against cardiovascular disease.

A population-scale red blood cell proteome reveals genetically encoded aging clocks predictive of hemolysis and blood donor activity

This paper characterizes the RBC proteome across 13,091 donors, identifies genetic regulators of molecular aging, and shows that aging clocks predict hemolysis, transfusion outcomes, and donor activity.

Random forest classifiers trained on simulated data enable accurate short read-based genotyping of structural variants in the alpha globin region at Chr16p13.3

The paper uses random forest classifiers trained on simulated data to accurately genotype structural variants in the alpha globin region, outperforming existing software in ancestry-specific allele frequency estimation.