Rachael Natrajan

Inference of Cancer Drug Cross Resistance Using Only Single-Drug Exposure Data

This paper identifies cross resistance between cancer drugs using single-drug exposure data, showing that high cross resistance reduces the effectiveness of switching between CDK4/6 inhibitors.

FAK Inhibition Remodels the Metastatic ECM and Restores CD8+ T Cell Trafficking and Immunosurveillance

This paper shows that FAK inhibition remodels the metastatic ECM, enhancing CD8+ T cell infiltration and immunosurveillance in breast cancer.

Multimodal profiling unveils a reversible breast basal-like cell state in AKT-inhibitor resistant tumours

This study identifies a reversible basal-like cell state in AKT-inhibitor resistant triple negative breast cancer using multimodal profiling and lineage tracing.