Erik C. Andersen

The paper identifies thousands of expression STRs (eSTRs) that regulate gene expression beyond SNV-based loci in C. elegans and links antioxidant gene expression to STR variation.

This study identifies genomic signatures of benzimidazole drug resistance in Haemonchus contortus using field populations with defined treatment histories, showing the isotype-1 β-tubulin gene as the primary resistance locus.

The paper identifies natural variation in the irld gene family affecting starvation resistance in C. elegans using MIP-seq and genome-wide association.

This paper introduces an automated method for quantifying chemotaxis index in C. elegans using liquid-handling robots and a custom image analysis tool.

This study identifies three QTL associated with body size variation in C. elegans using linkage mapping between two strains.

The paper generates chromosome-level reference genomes for two C. briggsae strains, improving genomic resources for comparative genomics in the Caenorhabditis genus.

The paper investigates the role of C. elegans β-tubulin genes in albendazole resistance, finding that tbb-2 modifies sensitivity and ben-1 mutations primarily confer resistance.

The paper maps gene expression variation across 207 C. elegans wild strains to identify regulatory hotspots and their links to phenotypic traits.

The paper measures body shape and growth in C. elegans during development, finds shape changes without volume change, and models cuticle stretch as a mechanism for growth control.

This study identifies four new beta-tubulin alleles in parasitic nematodes that confer resistance to benzimidazoles and show no significant fitness costs.

This study evaluates genome-wide association mapping in C. elegans using simulations and a new pipeline, showing increased power with more strains and lower false discovery rates in recently selected populations.

easyXpress is an R package for analyzing and visualizing high-throughput C. elegans microscopy data from CellProfiler, offering customizable filtering and interactive visualization tools.

The paper links natural variation in fertility to genomic divergence in C. elegans by identifying QTL associated with fertility and correlating them with selective sweeps.

The paper identifies three genomic regions in C. elegans associated with natural variation in macrocyclic lactone response, including two novel loci and one previously known locus.

The paper identifies a gene, sqst-5, associated with zinc resistance in C. elegans by analyzing genetic variation between strains with different zinc responses.

The paper identifies genetic modifiers of propionate sensitivity in C. elegans using genome-wide association mapping and shows that natural variation in GLCT-3 modulates this trait.

This study demonstrates that five beta-tubulin alleles confer benzimidazole resistance in parasitic nematodes and shows that E198V reduces fitness in the absence of the drug.

The paper identifies a single gene, scb-1, as a pleiotropic locus underlying variation in Caenorhabditis elegans responses to multiple chemotherapeutics.

The paper shows that polygenic demographic variation in C. elegans is driven by tightly-linked antagonistic-effect loci, with large-effect variants masked by epistasis or linkage disequilibrium.

This study identifies a nematode-specific gene, scb-1, as a genetic determinant of bleomycin-response variation in C. elegans using linkage mapping and CRISPR-Cas9 experiments.

This study identifies a genetic variant in C. elegans that affects arsenic toxicity through differences in branched-chain amino acid metabolism.

The paper shows that copy-number variation of pheromone receptor genes in C. elegans is shaped by selection and gene flow, contributing to differences in pheromone responses across habitats.

The paper identifies a beneficial genomic rearrangement in C. elegans that creates multiple versions of the rcan-1 gene, enhancing fitness and exploration behavior.

The paper investigates natural variation in sperm size among C. elegans strains and identifies genetic factors, particularly nurf-1, influencing male sperm size and competitive ability.

This study identifies extreme allelic heterogeneity in the ben-1 gene of C. elegans as a major determinant of natural resistance to albendazole, revealing multiple mechanisms of benzimidazole resistance.

The paper identifies QTL underlying toxin response variation in C. elegans and validates their contributions through experimental assays.

The paper identifies QTL associated with benzimidazole resistance in nematodes using genetic mapping and phenotyping.

The paper identifies a single amino acid substitution in topoisomerase II that explains variation in drug sensitivity across C. elegans isolates and human cell lines.