yeast

This study develops biosensors for MIAs and identifies metabolic engineering hits to enhance MIA production in yeast.

This study identifies evolutionary patterns of gene gain and loss in fission yeasts, revealing how metabolic genes contribute to diversification and link carbon metabolism to sexual reproduction.

The paper uses machine learning to predict yeast fitness across 35 environments using genetic variants, finding that copy number variants explain most fitness variation and that gene contributions depend on isolate and environment.

The paper examines regulatory divergence in Saccharomyces yeasts and finds that while cis and trans regulatory effects are widespread, hybrid gene expression remains largely conserved due to compensatory divergence.

Bromo, a pairwise transformer, ranks a protein's peptide precursors by expected mass spectrometry response, beating XGBoost, PREGO and PeptideRanger on held-out yeast data, and can be fine-tuned per instrument.

This paper enables combinatorial metabolic engineering in Debaryomyces hansenii by developing genetic parts and integration loci, resulting in a high titer of heptadecane production.

This study shows that yeast Dhx29 unwinds structured mRNA in the ribosomal A-site during translation elongation, resolving hairpin structures and preventing ribosome collisions.

The paper investigates nitrate assimilation in B. bruxellensis lineages using genomic and phenotypic data, finding it is widespread but unevenly distributed and influenced by gene copy number and functionality.

The paper identifies Tom70 as a regulator of nuclear pore complex exclusion during gametogenesis in yeast by mediating mitochondria-nuclear envelope contacts.

This paper investigates the role of the β-hairpin loop in the SUI1 domain of DENR/Tma22p in yeast, showing its critical function in ribosome recycling and reinitiation.

The paper identifies a conserved interaction between Bim1 and the Ndc80 complex in S. cerevisiae, showing it enhances microtubule attachment strength and is regulated by phosphorylation.

The paper introduces a modular framework for designing eukaryotic transcription factors by separating functional domains and using synthetic promoters to control gene regulation.

The paper uses high-content imaging and machine learning to study how perturbing essential genes affects subcellular organization in yeast, revealing cascade effects and a threshold for cell death.

The paper sequenced Norwegian farmhouse yeasts to study their genetic diversity and domestication history, finding they form an early diverging lineage with distinct phylogenetic and population genetic characteristics.

This study shows that the pyruvate dehydrogenase complex (PDHc) associates with mtDNA-containing assemblies in yeast, supporting mitochondrial translation through an RNA-dependent mechanism.

This study resolves the debate on the origin of taxonomically restricted genes in yeast by showing most are de novo genes while others derive from diverged ancestors.

This study identifies a conserved interaction between Bim1 and the Ndc80 complex in S. cerevisiae, showing it enhances microtubule attachment strength and is regulated by phosphorylation.

The paper uses mitochondrial ribosome content to infer metabolic activity in yeast, finding a strong linear correlation with oxygen uptake rate.

This study evaluates AI-prioritized antimicrobial peptides derived from Malassezia furfur genomes, showing their antimicrobial activity and highlighting AI prediction biases.

This study uses MINFLUX to track yeast dynein stepping dynamics at high resolution, revealing ATP hydrolysis per step and 8 nm steps with transient plus-end movements.

The paper develops an automated image processing pipeline for analyzing yeast cell cycle dynamics using deep learning and dual segmentation, achieving faster analysis with minimal deviation from manual methods.

This study identifies Gim3 as a critical regulator of meiotic chromosome segregation in budding yeast, revealing its role in spindle sensitivity to tubulin levels and meiotic cellular remodeling.

This study identifies Ghs2 as a binding partner of Bgs3 in fission yeast, showing they co-localize and work together to synthesize and branch β-1,3-glucan in the fungal cell wall.

The paper samples and analyzes Saccharomycotina yeasts in subtropical forest leaf litter, revealing high culturable diversity and seasonal dynamics linked to climate factors.

This study shows that compressive force from the nuclear envelope in S. pombe affects spindle biochemistry by altering microtubule dynamics and protein distribution.

This study identifies a conserved role of cystinosin/Ers1 in the early secretory pathway, revealing new insights into cystinosis pathology beyond lysosomal cystine transport.

This study improves carbon efficiency in autotrophic yeast by redirecting methanol dissimilation through alcohol dehydrogenase, increasing biomass yield and product titers.

The paper investigates how gene-level complexity influences genome-wide variation in the distribution of fitness effects across species.

This study uses NMR to show phosphorylation alters the structure and interactions of the Ycf1p R region, affecting ATPase activity and NBD interactions in ABC transporters.

This paper establishes a haploid yeast strain collection to study ecological and reproductive divergence in wild S. cerevisiae, finding that structural genomic variation and metabolic gene divergence drive these traits.