yeast

This study shows indaziflam, a cellulose biosynthesis inhibitor herbicide, only affects organisms with cellulose-containing cell walls, not those with chitin or glycoprotein walls.

The paper uses deep mutational scanning to analyze resistance mutations in Fks1, revealing distinct resistance landscapes for echinocandins and triterpenoids, including a novel triterpenoid-specific hotspot.

This study identifies extensive horizontal gene transfer in the fungus gnat Bradysia coprophila, showing these genes contribute to stress tolerance and ecological adaptation.

The paper uses R-DeeP to show stress-induced compartment-specific RNA buffering of protein aggregation in yeast, with nuclear RNA retention protecting nuclear proteins from aggregation.

The paper develops a pipeline to collect, characterize, and scale wild yeast for beer brewing, identifying interventions to overcome industrial fermentation challenges.

The paper uses computational methods to analyze antioxidant effects on stress response mechanisms in Candida albicans, identifying naringenin and quercetin as potential modulators of Sir2/SIRT3 pathways.

This paper develops a tunable auxin-based trans-kingdom signaling system that enables cross-species communication by engineering auxin biosynthesis and response mechanisms in different organisms.

The paper identifies Saccharomyces cerevisiae and Saccharomyces jurei hybrids with improved oenological traits for wine fermentation.

The paper shows Scm3HJURP facilitates Cse4CENP-A deposition at native centromeres by interacting with Ndc10, enhancing Cse4 assembly efficiency in yeast.

This study shows that polyploidy leads to reduced mitochondrial scaling and impaired metabolic function, with conserved effects across yeast and human cells.

This study identifies Ume6 as a transcriptional repressor that regulates vacuolar protein composition and autophagy in yeast by interacting with Rph1 and being modulated by protein kinases.

This paper identifies Yra2's role in ubiquitin-mediated proteolysis of Cse4 to prevent its mislocalization and maintain chromosomal stability in budding yeast.

The paper identifies two regulatory elements in Lte1 that coordinate kinase activity to compartmentalize Lte1 at the bud cortex in S. cerevisiae, ensuring proper mitotic exit.

This study identifies Kcs1-dependent inositol pyrophosphates as regulators of DNA repair via Pho80-Pho85 in budding yeast, independent of homologous recombination.

The paper investigates how PRPS1 disease alleles affect polymerization and cytoskeletal organization in yeast and human cells, linking these changes to metabolic state and phenotypic overlap.

This study compares multi-omics data from yeast-derived extracellular vesicles to show conserved membrane architecture and strain-specific metabolic cargo enrichment.

This study uses yeast large-scale absolute quantitative proteomics to reveal universal principles of protein resource allocation among cellular organelles and its relationship to physiological parameters and species divergence.

BUDDY is a web platform that streamlines the functional modeling of human missense variants using yeast orthologs, reducing bioinformatic preparation time and enabling non-experts to design experiments.

This paper adapts a fluorescence-based method to detect mistranslation in yeast and shows it detects mistranslation events differently than mass spectrometry.

This paper combines TMT and DIA proteomics techniques to improve low-input proteomics, showing how to overcome co-isolation interference and enabling TMT quantification with DIA-focused software.

This study shows Rad53/Chk2 links mitochondrial function and ROS levels to G2/M cell cycle progression in yeast.

VaLPAS pairs a bi-directional autoencoder with correlation for omics guilt-by-association with calibrated confidence; in L. starkeyi its autoencoder linked 176 unidentified metabolites to known-function proteins at ≥50% confidence.

This study shows that deleting Scp160 reduces TDP-43 aggregation and toxicity in yeast, while Bfr1 has a lesser effect.

The paper improves GPCR biosensors in yeast using a new platform called HERO, achieving significant sensitivity gains through directed evolution.

The paper uses a limit-pushing approach in yeast to measure protein abundance and toxicity, finding that overexpression tolerance varies with protein characteristics and can lead to distinct intracellular states.

This study shows that clathrin adaptors Ent5 and Sla2 undergo liquid-liquid phase separation, with distinct structural features driving condensate formation and function in endocytosis and trafficking.

This study measures proteome-wide translation errors in yeast and mouse, finding that fidelity varies by organism and tissue, increases with age in post-mitotic cells, and is regulated by tRNA pool remodeling.

The paper shows that RNase T2-mediated RNA degradation is essential for maintaining phosphate homeostasis in S. cerevisiae, even under phosphate-replete conditions.