protein structure prediction

This study determines the structure of full-length human hephaestin using cryo-EM, revealing its homodimeric organization and substrate-binding site.

This study determines the cryo-EM structures of human claudin-18.2 bound to therapeutic antibodies, revealing key residues involved in antibody recognition.

The paper characterizes LOca-1, a calcium-activated arginyl-specific orthocaspase from Loki's Castle, showing its thermoactivity and structural conservation with plant metacaspases.

The paper identifies bacterial MVP homologs and reports cryoEM structures of vaults from Corallococcus praedator and a Deltaproteobacteria bacterium, revealing novel symmetries.

The paper predicts a cohesin acetylation complex in budding yeast that interacts with nicked DNA and confirms its function through experiments.

The paper reports the cryo-EM structures of an Acinetobacter baumannii podovirus, revealing its capsid maturation mechanism and providing a reference for phage engineering.

This study determines cryo-EM structures of FcR bound to IgM and IgA, revealing its binding mechanism and evolutionary insights into pIg receptor recognition.

This study reports cryo-EM structures of human PAT-1 with inhibitors to elucidate their inhibition mechanisms and domain interactions.

This study shows that IFI16 filament assembly provides mechanical stability to condensates by compacting DNA into ultra-stable tangles, contrasting with the sensitivity of HIN200-dsDNA complexes.

This study identifies INMT's localization near the Golgi apparatus in human neurons and suggests it creates a region for psychedelic tryptamine biosynthesis.

This study investigates how charge and conformational changes in a peptide affect its binding to different snake venom PLA2 variants, revealing structural and electrostatic factors influencing affinity.

This study identifies 'unlatching' as a common mechanism for Parkinson's disease-associated LRRK2 variants, showing increased membrane localization and decreased S935 phosphorylation.

The paper shows Scm3HJURP facilitates Cse4CENP-A deposition at native centromeres by interacting with Ndc10, enhancing Cse4 assembly efficiency in yeast.

AA-20 promotes lipophagy by activating lysosomal acid lipase and CDK5, reducing lipid droplet accumulation and improving neurodegeneration-associated phenotypes in cellular and organoid models.

This study reports cryo-EM structures of phage OE33PA, revealing a dynamic adhesion device that mediates Gram-positive host recognition through receptor-binding proteins and a hexameric tape measure protein.

This study determines the structure of influenza D virus NS1, identifies a novel Zn-binding site and RNA-binding activity in its CTD, and shows their importance for viral replication.

The paper presents an integrated experimental and informatics strategy to improve identification of large proteoforms in top-down proteomics, achieving identification of proteoforms up to 223 kDa.

The paper structures ZmaM, a type II peptidase-ABC transporter in B. cereus, showing it activates and exports zwittermicin A by coordinating peptidase and transporter modules.

This study reports cryo-EM structures of full-length BCRs, revealing their dynamic conformation and antigen binding-induced signaling mechanisms.

This study identifies NDE1's localization at subdistal appendages and shows its role in maintaining centrosome integrity and microtubule organization through interactions with other proteins.

The paper presents the structure and functional properties of a BCOL protein from the lancelet Branchiostoma floridae, revealing structural and sequence differences from other CCDs.

This study reports the cryo-EM structure of Pdr5, showing ergosterol binding and its effect on transporter activity, with implications for fungal drug resistance.

This paper establishes a robust workflow for injector-based pump-probe TR-SSX at the MicroMAX beamline to study CrPhotLOV1 structural dynamics.

This study maps SARS-CoV-2 protein-RNA interactions using eCLIP, revealing new regulatory sites for viral replication and translation.

The paper investigates how a bacterial chaperone-usher pathway enables interkingdom protection of a fungus from antimicrobial compounds.

This study identifies Ume6 as a transcriptional repressor that regulates vacuolar protein composition and autophagy in yeast by interacting with Rph1 and being modulated by protein kinases.

This study investigates how ANKB regulates cardiomyocyte sarcomere structure and shows that the p.S646F variant alters its protein interactions, leading to structural abnormalities.

The paper reports room-temperature light-state structures of AsLOV2-Rac1 using serial femtosecond crystallography, revealing structural changes upon light activation.

The paper identifies a PUFA binding site on ASIC3 using MD simulations and electrophysiology, showing how DHA modulates channel gating and desensitization.

The paper identifies RvPeti, a novel metalloprotease from a tardigrade, through structural and biochemical analysis, revealing its Zn2+-dependent proteolytic activity.